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Midazolam as Adjunct Therapy to Morphine in the Alleviation of Severe Dyspnea Perception in Patients with Advanced Cancer  Alfredo H. Navigante, MD, PhD,

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Presentation on theme: "Midazolam as Adjunct Therapy to Morphine in the Alleviation of Severe Dyspnea Perception in Patients with Advanced Cancer  Alfredo H. Navigante, MD, PhD,"— Presentation transcript:

1 Midazolam as Adjunct Therapy to Morphine in the Alleviation of Severe Dyspnea Perception in Patients with Advanced Cancer  Alfredo H. Navigante, MD, PhD, Leandro C.A. Cerchietti, MD, Monica A. Castro, MD, Maribel A. Lutteral, MD, Maria E. Cabalar, MD  Journal of Pain and Symptom Management  Volume 31, Issue 1, Pages (January 2006) DOI: /j.jpainsymman Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Flow of patients during the study.
Journal of Pain and Symptom Management  , 38-47DOI: ( /j.jpainsymman ) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Fig. 2 Percentage of patients who experienced dyspnea relief at 24 hours. ∗P = compared with MM. ∗∗P = compared with MM. Journal of Pain and Symptom Management  , 38-47DOI: ( /j.jpainsymman ) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Fig. 3 Dyspnea intensity (Borg scale) at 24 and 48 hours (median). ∗P = 0.002, ∗∗P = 0.018, ∗∗∗P = compared with their respective baseline values. #P = , ##P = , ###P < compared with their respective baseline values. Journal of Pain and Symptom Management  , 38-47DOI: ( /j.jpainsymman ) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

5 Fig. 4 Percentage of patients with persistent, uncontrolled dyspnea at 48 hours. ∗P = 0.04 compared with MM. Journal of Pain and Symptom Management  , 38-47DOI: ( /j.jpainsymman ) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

6 Fig. 5 Episodes of BD. Journal of Pain and Symptom Management  , 38-47DOI: ( /j.jpainsymman ) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions


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