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Volume 44, Issue 6, Pages (June 2006)

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1 Volume 44, Issue 6, Pages 1167-1174 (June 2006)
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2  John Willy Haukeland, Jan Kristian Damås, Zbigniew Konopski, Else Marit Løberg, Terese Haaland, Ingeborg Goverud, Peter A Torjesen, Kåre Birkeland, Kristian Bjøro, Pål Aukrust  Journal of Hepatology  Volume 44, Issue 6, Pages (June 2006) DOI: /j.jhep Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 Box plots showing interquartile range (box), median (thick line), range (thin lines) and outliers (circles) for A serum TNF-α, B serum CCL2/MCP-1 and C serum adiponectin in healthy controls, in patients with simple steatosis and in patients with NASH. *P<0.05 and **P<0.001 vs controls. #P<0.05 vs simple steatosis. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 Immunohistochemical staining for CCL2/MCP-1 in liver tissue from two patients with NASH. Original magnification ×160. (A) Portal inflammation with positive staining (dense brownish) in bile duct epithelium (upper arrowhead), endothelium (lower arrowhead) and leukocytes (arrows). (B) Centrilobular area with severe steatosis, positive staining is observed in leukocytes accumulating around a fat vacuole (arrow). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions


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