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Figure 18.1 Stereospecific numbering of glycerol.

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Presentation on theme: "Figure 18.1 Stereospecific numbering of glycerol."— Presentation transcript:

1 Figure 18.1 Stereospecific numbering of glycerol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

2 Figure 18.2 Structure of some common polar groups of phospholipids.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

3 Figure Generalized structure of a phospholipid where R1 and R2 represent the aliphatic chains of fatty acids, and R3 represents a polar group. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

4 Figure 18.4 Structures of some common phospholipids.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

5 Figure 18.5 Structures of phosphatidylglycerol and phosphatidylinositol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

6 Figure 18.6 Structure of cardiolipin.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

7 Figure 18.7 Structure of ethanolamine plasmalogen.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

8 Figure 18.8 Structure of platelet activating factor (PAF).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

9 Figure 18.9 Role of surfactant in preventing atelectasis.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

10 Figure 18.10 Structure of phosphatidylinositol 4,5-bisphosphate (PIP2 or PtdIns (4,5)P2).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

11 Figure Generation of 1,2-diacylglycerol and inositol 1,4,5-trisphosphate by action of phospholipase C on phosphatidylinositol 4,5-bisphosphate. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

12 Figure Pathways for the synthesis and removal of intracellular inositol 1,4,5-trisphosphate and diacylglycerol. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

13 Figure Phosphatidic acid biosynthesis from glycerol 3-phosphate and the role of phosphatidic acid phosphatase in synthesis of phospholipids and triacylglycerols. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

14 Figure 18.14 Biosynthesis of CDP-choline from choline.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

15 Figure 18.15 Choline phosphotransferase reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

16 Figure Biosynthesis of phosphatidylcholine from phosphatidylethanolamine and S-adenosylmethionine (AdoMet); S-adenosylhomocysteine (AdoHcys) Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

17 Figure Biosynthesis of phosphatidylethanolamine from CDP-ethanolamine and diacylglycerol; the reaction is catalyzed by ethanolamine phosphotransferase. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

18 Figure 18.18 Formation of phosphatidylethanolamine by the decarboxylation of phosphatidylserine.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

19 Figure Biosynthesis of phosphatidylserine from serine and phosphatidylethanolamine by base exchange. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

20 Figure 18.20 Biosynthesis of phosphatidylinositol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

21 Figure 18.21 Reactions catalyzed by phospholipase A1 and phospholipase A2.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

22 Figure 18.22 Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

23 Figure Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

24 Figure 18.24 Two pathways for biosynthesis of dipalmitoyllecithin from sn-1 palmitoyllsolecithin.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

25 Figure 18.25 Pathway of choline plasmalogen biosynthesis from DHAP.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

26 Figure 18.26 The cyclopentenophenanthrene ring.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

27 Figure Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

28 Figure 18.28 Structure of cholesteryl (palmitoyl-) ester.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

29 Figure 18.29 Structure of ergosterol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

30 Figure 18.30 HMG-CoA synthase reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

31 Figure 18.31 HMG-CoA reductase reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

32 Figure 18.32 Formation of farnesyl-PP (F) from mevalonate (A).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

33 Figure 18.33 Formation of squalene from two molecules of farnesyl pyrophosphate.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

34 Figure 18.34 Structure of squalene (C30).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

35 Figure 18.35 Conversion of squalene 22,3-epoxide to lanosterol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

36 Figure 18.36 Conversion of lanosterol to cholesterol.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

37 Figure 18.37 Organs and pathways involved in plasma lipoprotein metabolism.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

38 Figure 18.38 Reverse cholesterol transport showing the proteins and enzymes involved.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

39 Figure 18.39 Lecithin: cholesterol acyltransferase (LCAT) reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

40 Figure Summary of cholesterol synthesis indicating feedback inhibition of HMG-CoA reductase by cholesterol. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

41 Figure 18.41 Structure of cholanic acid.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

42 Figure 18.42 Structures of some common bile acids.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

43 Figure 18.43 Structure of glycocholic acid, a conjugated bile acid.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

44 Figure Comparison of structures of glycerol and sphingosine (trans-1,3-dihydroxy-2-amino-4-octadecene). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

45 Figure 18.45 Formation of 4-ketodihydrosphingosine from serine and palmitoyl CoA.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

46 Figure 18.46 Conversion of 3-ketodihydrosphingosine to sphinganine.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

47 Figure 18.47 Structure of a ceramide (N-acylsphingosine).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

48 Figure 18.48 Formation of ceramide from dihydrosphingosine.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

49 Figure 18.49 Structures of some common sphingolipids in diagrammatic form.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

50 Figure 18.50 Structure of sphingomyelin.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

51 Figure 18.51 Sphingomyelin synthesis from ceramide and phosphatidylcholine.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

52 Figure 18.52 Structure of galactocerebroside (galactolipid).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

53 Figure 18.53 Structure of glucocerebroside.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

54 Figure 18.54 Synthesis of galacto- and glucocerebrosides.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

55 Figure 18.55 Structure of galactocerebroside sulfate (sulfolipid).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

56 Figure 18.56 Structure of PAPS (3’-phosphoadenosine-5’phosphosulfate).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

57 Figure 18.57 Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

58 Figure 18.58 Structure of N-acetylneuraminic acid (NANA).
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

59 Figure 18.59 Summary of the pathways for catabolism of sphingolipids by lysosomal enzymes.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

60 Figure 18.60 Sphingomyelinase reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

61 Figure Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

62 Figure 18.62 Structures of the major prostaglandins.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

63 Figure 18.63 Structure of prostanoic acid.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

64 Figure 18.64 Synthesis of E and F prostaglandins from fatty acid precursors.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

65 Figure 18.65 Cyclooxygenase reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

66 Figure 18.66 Conversion of PGG2 to PGH2; PG hydroperoxidase (PGH synthase) reaction.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

67 Figure 18.67 Major routes of prostaglandin biosynthesis.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

68 Figure 18.68 Synthesis of TXB2 from PGH2.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

69 Figure 18.69 Site of action of inhibitors of prostaglandin synthesis.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

70 Figure Lipoxygenase reaction and role of 5-hydroperoxyeicosatetraenoic acids (HPETEs) as precursors of hydroxyeicosatetraenoic acids (HETEs). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

71 Figure 18.71 Conversion of 5-HPETE to LTB4 and LTC4 through LTA4 as intermediate.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

72 Figure 18.72 Conversion of LTC4 to LTD4 and LTE4.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

73 Figure 18.73 Synthesis of Lipoxins.
Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.


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