1. Preventing Postoperative Recurrence of Crohn's Disease: How Can We Improve Results? 
R. Balfour Sartor, MD 
Clinical Gastroenterology and Hepatology 
Volume 13, Issue 5, Pages (May 2015)
DOI: /j.cgh
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2. Figure 1
Active Crohn's disease (A) is characterized by bacterial dysbiosis, mucosal ulceration, activated innate and TH1/TH17 adaptive immune responses, and dysmorphic Paneth cells. Systemic factors modify gut inflammation. After resection (B) all visible disease and inflammation are removed. The goal of future, more physiologic therapy is to restore and maintain mucosal homeostasis by correcting bacterial imbalance, enhancing mucosal barrier function and innate defenses, and correcting immunoregulatory defects to prevent relapse of mucosal ulceration and clinical recurrence without the toxicity of long-term immunosuppressive medications. IFN, interferon; Ig, immunoglobulin; IL, interleukin; mAb, monoclonal antibody; TGF, transforming growth factor; TNF, tumor necrosis factor.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh )
Copyright © 2015 AGA Institute Terms and Conditions