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The Proteasome: Not Just Degrading Anymore

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1 The Proteasome: Not Just Degrading Anymore
Stephen P. Baker, Patrick A. Grant  Cell  Volume 123, Issue 3, Pages (November 2005) DOI: /j.cell Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 The Proteasome Functions in Multiple Facets of Transcription
The proteasome 19S RP assists in the Gal4-dependent recruitment of the SAGA acetyltransferase complex to target promoters, leading to enhanced acetylation (Ac) of histone H3 (A) and is required for efficient transcription elongation (B). Furthermore, the 26S holoenzyme (20S and two 19S RP subunits) can proteolytically remove stalled, polyubiquitylated RNA polymerase II at termination sites or sites of DNA damage (C). Cell  , DOI: ( /j.cell ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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