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CD4+ T cells migrate from airway to bone marrow after antigen inhalation in rats  Susumu Isogai, MD, Shigeru Miyata, MD, Rame Taha, MD, Yasuyuki Yoshizawa,

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Presentation on theme: "CD4+ T cells migrate from airway to bone marrow after antigen inhalation in rats  Susumu Isogai, MD, Shigeru Miyata, MD, Rame Taha, MD, Yasuyuki Yoshizawa,"— Presentation transcript:

1 CD4+ T cells migrate from airway to bone marrow after antigen inhalation in rats 
Susumu Isogai, MD, Shigeru Miyata, MD, Rame Taha, MD, Yasuyuki Yoshizawa, MD, James G Martin, MD, Qutayba Hamid, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 3, Pages (March 2004) DOI: /j.jaci

2 FIG 1 Fluorescence confocal microscopic images (magnification ×400) showing representative examples of CFSE-stained CD4+ T cells before being placed in the trachea (A). CFSE-positive cells in the BAL (B) and in the spleen (C) 24 hours after OVA challenge of an OVA-sensitized rat. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

3 FIG 2 The number of CFSE-positive CD4+ T cells in BAL, left lung, marginal blood pool of the lungs, draining lymph nodes of the lungs, peripheral blood, and bone marrow compartments of recipients. Primed T-cell transferred, OVA-sensitized, OVA-challenged group (OVA-OVA/OVA), primed T-cell transferred, sham-sensitized, OVA-challenged group (OVA-PBS/OVA), and naive T-cell transferred, sham-sensitized, OVA-challenged group (naive-PBS/OVA) are shown. The means and standard errors are shown. Significant differences are indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

4 FIG 3 The number of MBP-positive cells in bone marrow was determined by immunocytochemistry. The means and standard errors are shown. Significant differences are indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

5 FIG 4 The number of eosinophils in BAL was evaluated by Wright-Giemsa staining. The means and standard errors are shown. Significant differences are indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

6 FIG 5 MBP-positive cells in bone marrow of OVA-sensitized, OVA-challenged recipients of primed T cells were evaluated by immunocytochemistry by means of the APAAP technique and Fast Red staining (A) and in PBS-sensitized and OVA-challenged recipients of primed T cells (B) (magnification ×400). IL-16–positive cells in bone marrow of OVA-sensitized, OVA-challenged recipients of primed T cells (C) and in PBS-sensitized and OVA-challenged recipients of primed T cells (D) (magnification ×200). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

7 FIG 6 The expression of eotaxin (upper panel) and the expression of IL-16 (lower panel) in primed T-cell transferred, OVA-sensitized, OVA-challenged group (OVA-OVA/OVA), primed T-cell transferred, sham-sensitized, OVA-challenged group (OVA-PBS/OVA), and naive T-cell transferred, sham-sensitized, OVA-challenged group (naive-PBS/OVA). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

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