Presentation is loading. Please wait.

Presentation is loading. Please wait.

Selective renal blood perfusion induces renal tubules injury in a porcine model  Johannes Kalder, MD, Maria Kokozidou, DVM, MSc, PhD, Paula Keschenau,

Published byΒαρβάρα Βουρδουμπάς Modified over 5 years ago

Similar presentations

Presentation on theme: "Selective renal blood perfusion induces renal tubules injury in a porcine model  Johannes Kalder, MD, Maria Kokozidou, DVM, MSc, PhD, Paula Keschenau,"— Presentation transcript:

1 Selective renal blood perfusion induces renal tubules injury in a porcine model 
Johannes Kalder, MD, Maria Kokozidou, DVM, MSc, PhD, Paula Keschenau, MD, Miriam Tamm, Andreas Greiner, MD, PhD, Thomas A. Koeppel, MD, PhD, Rene Tolba, MD, PhD, Michael J. Jacobs, MD, PhD  Journal of Vascular Surgery  Volume 63, Issue 3, Pages (March 2016) DOI: /j.jvs Copyright © 2016 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Experimental setting of the (a) distal aortic perfusion (DAP) and the (b and c) added selective renal perfusion (SRP). ECC, extracorporeal circulation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Mean arterial blood pressure measurements were taken from the common carotid artery during the entire procedure in cohort I, and at times T1, T4, T5, and T6 in cohorts II and III. At T2 and T3, the pressure was measured in cohort II with an intra-aortic catheter below the thoracic aortic cross-clamp (TAC) and in cohort III at the tip of the perfusion catheters. The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Flow rates were measured during the experiment at the origins of both renal arteries. The plotted values are the added values of both renal arteries. During the selective renal perfusion (SRP) the flow rates were measured at the selective tubing system. The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Microcirculation measured by 15-μm fluorescent microspheres injected into the descending aorta or at T2 and T3 into the tubing system of the extracorporeal circulation (ECC) behind the oxygenator. The P values are given for log-transformed data (cohort I: n = 5, cohort II: n = 5, cohort III: n = 6). The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Calculated renal oxygen extraction ratio (O2ER) of the right kidney. The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; SRP, selective reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

7 Fig 6 A, Measured pH levels of the samples from the right renal vein. B, Calculated differences between renovenous and the aortic pH serum levels are shown. 1-Sensitivity analysis (without pig 10): P = (cohort I: n = 5, cohort II: n = 5; cohort III: n = 6). The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

8 Fig 7 A, Measured base excess in mm/L from the venous sample of the right renal vein. B, Calculated difference between the renovenous base excess and the aortic base excess are shown in mmol/L. The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

9 Fig 8 Measured creatinine serum levels. The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

10 Fig 9 A, Measured renovenous neutrophil gelatinase-associated lipocalin (NGAL) levels (cohort I: n = 4, cohort II, n = 4; cohort III: n = 5). B, Urinary creatinine normalized urinary NGAL levels (cohort I: n = 3, cohort II: n = 2, cohort III: n = 5). The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

11 Fig 10 A, Serum free hemoglobin values. B, Lactate dehydrogenase (LDH) levels (cohort I: n = 4, cohort II: n = 6, cohort III: n = 6). The error bars show the standard deviation. DAP, Distal aortic perfusion; SOP, selective organ perfusion; T1, after surgical preparation; T2, beginning of the main procedure; T3, end of the main procedure; T4, 15 minutes of reperfusion; T5, 60 minutes of reperfusion; T6, 120 minutes of reperfusion; TAC, thoracic aortic cross-clamping. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Download ppt "Selective renal blood perfusion induces renal tubules injury in a porcine model  Johannes Kalder, MD, Maria Kokozidou, DVM, MSc, PhD, Paula Keschenau,"

Similar presentations

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages 1072-1082 (October 2014) DOI:

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:
J. Hajo van Bockel, MD, Pieter J. van den Akker, MD, Peter C

J. Hajo van Bockel, MD, Pieter J. van den Akker, MD, Peter C
Intraaortic Counterpulsation During Cardiopulmonary Bypass Impairs Distal Organ Perfusion  Steinar Lundemoen, MD, Venny Lise Kvalheim, MD, PhD, Øyvind.

Intraaortic Counterpulsation During Cardiopulmonary Bypass Impairs Distal Organ Perfusion  Steinar Lundemoen, MD, Venny Lise Kvalheim, MD, PhD, Øyvind.
Brain and spinal cord protection during simultaneous aortic arch and thoracoabdominal aneurysm repair  Gottfried Mommertz, MD, Stephan Langer, MD, Thomas.

Brain and spinal cord protection during simultaneous aortic arch and thoracoabdominal aneurysm repair  Gottfried Mommertz, MD, Stephan Langer, MD, Thomas.
The impact of selective visceral perfusion on intestinal macrohemodynamics and microhemodynamics in a porcine model of thoracic aortic cross-clamping 

The impact of selective visceral perfusion on intestinal macrohemodynamics and microhemodynamics in a porcine model of thoracic aortic cross-clamping 
Bedside vena cava filter placement with intravascular ultrasound: A simple, accurate, single venous access method  Donald L. Jacobs, MD, Raghunandan L.

Bedside vena cava filter placement with intravascular ultrasound: A simple, accurate, single venous access method  Donald L. Jacobs, MD, Raghunandan L.
Michael Zhen-Yu Tong, MBA, MD, Pavan Koka, MD, Thomas L. Forbes, MD 

Michael Zhen-Yu Tong, MBA, MD, Pavan Koka, MD, Thomas L. Forbes, MD 
Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair  Catherine K. Chang,

Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair  Catherine K. Chang,
Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model  Paula Rosalie Keschenau, MD, Stefanie Ribbe, Miriam.

Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model  Paula Rosalie Keschenau, MD, Stefanie Ribbe, Miriam.
Factors Affecting Systemic Oxygen Delivery After Norwood Procedure With Sano Modification  Yuji Naito, MD, Mitsuru Aoki, MD, Manabu Watanabe, MD, Nobuyuki.

Factors Affecting Systemic Oxygen Delivery After Norwood Procedure With Sano Modification  Yuji Naito, MD, Mitsuru Aoki, MD, Manabu Watanabe, MD, Nobuyuki.
Postoperative renal failure in thoracoabdominal aortic aneurysm repair with simple cross-clamp technique and 4°C renal perfusion  Martha M. Wynn, MD,

Postoperative renal failure in thoracoabdominal aortic aneurysm repair with simple cross-clamp technique and 4°C renal perfusion  Martha M. Wynn, MD,
Renal perfusion with venous blood extends the permissible suprarenal clamp time in abdominal aortic surgery  Maximilian Pichlmaier, MA, MD, Ludwig Hoy,

Renal perfusion with venous blood extends the permissible suprarenal clamp time in abdominal aortic surgery  Maximilian Pichlmaier, MA, MD, Ludwig Hoy,
Hybrid treatment of an ascending aortic pseudoaneurysm following multiple sternotomies  Vito Giovanni Ruggieri, MD, Romain Malezieux, MD, Najeebullah.

Hybrid treatment of an ascending aortic pseudoaneurysm following multiple sternotomies  Vito Giovanni Ruggieri, MD, Romain Malezieux, MD, Najeebullah.
Walter J. Scott, M.D., Bruce L. Gewertz, M.D. 

Walter J. Scott, M.D., Bruce L. Gewertz, M.D. 
Revision using distal inflow is a safe and effective treatment for ischemic steal syndrome and pathologic high flow after access creation  Thomas M. Loh,

Revision using distal inflow is a safe and effective treatment for ischemic steal syndrome and pathologic high flow after access creation  Thomas M. Loh,
Glomerular filtration rate is superior to serum creatinine for prediction of mortality after thoracoabdominal aortic surgery  Tam T.T. Huynh, MD, Randolph.

Glomerular filtration rate is superior to serum creatinine for prediction of mortality after thoracoabdominal aortic surgery  Tam T.T. Huynh, MD, Randolph.
Johannes Kalder, MD, Dieudonne Ajah, Paula Keschenau, MD, Lieven N

Johannes Kalder, MD, Dieudonne Ajah, Paula Keschenau, MD, Lieven N
Prevention of paraplegia in pigs by selective segmental artery perfusion during aortic cross-clamping  Sven A. Meylaerts, MDa, Peter de Haan, MD, PhDb,

Prevention of paraplegia in pigs by selective segmental artery perfusion during aortic cross-clamping  Sven A. Meylaerts, MDa, Peter de Haan, MD, PhDb,
Christian A. P. Schmidt, MD, PhD, Markus J. Wilhelm, MD, Dieter O

Christian A. P. Schmidt, MD, PhD, Markus J. Wilhelm, MD, Dieter O
Endovascular stent graft for symptomatic mobile thrombus of the thoracic aorta  Philipp Fueglistaler, MD, Thomas Wolff, MD, Lorenz Guerke, MD, Peter Stierli,

Endovascular stent graft for symptomatic mobile thrombus of the thoracic aorta  Philipp Fueglistaler, MD, Thomas Wolff, MD, Lorenz Guerke, MD, Peter Stierli,

Similar presentations

Ads by Google