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Mitochondrial Fusion: Bax to the Fussure

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1 Mitochondrial Fusion: Bax to the Fussure
Seamus J. Martin  Developmental Cell  Volume 20, Issue 2, Pages (February 2011) DOI: /j.devcel Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Heterotypic and Homotypic Interactions between Mitofusins Promote Mitochondrial Fusion Mfn1 and Mfn2 can form homotypic and heterotypic complexes on opposing mitochondria to promote membrane tethering, followed by fusion. The data of Hoppins et al. (2011) suggest that Mfn1/Mfn2 interactions promote fusion more effectively than either Mfn1/Mfn1 or Mfn2/Mfn2 complexes. Hoppins et al. also observed that the Bcl-2 protein family members, Bax and Bcl-xL, enhanced mitochondrial fusion in an Mfn2-dependent manner. How they achieve this remains unclear. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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