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Emerging Approaches To Improve LDL-C Reduction in Hypercholesterolemia

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Presentation on theme: "Emerging Approaches To Improve LDL-C Reduction in Hypercholesterolemia"— Presentation transcript:

1 Emerging Approaches To Improve LDL-C Reduction in Hypercholesterolemia

2 Panelists

3

4 Dallas Heart Study: Lipid Characteristics of African Americans With Nonsense Mutations in PCSK9

5 ARIC: PCSK9 Loss-of-Function Mutations, LDL-C, and CHD Risk

6

7 SAR236553 Phase 2: Change in LDL-C at 4-Week Dosing Intervals on Atorvastatin

8 MENDEL: AMG 145 Phase 2 Monotherapy in Patients With Hypercholesterolemia

9 MENDEL: Effect of AMG 145 on Percentage Change in LDL-C From Baseline

10 LAPLACE-TIMI 57: Phase 2 AMG 145 in Combination With Statin in Patients With Hypercholesterolemia

11 LAPLACE-TIMI 57: Study Design

12 LAPLACE-TIMI 57: Effect of AMG 145 on Percentage Change in LDL-C From Baseline

13 LAPLACE-TIMI 57: Adverse Events

14 GAUSS: Phase 2 AMG 145 in Statin-Intolerant Patients

15 GAUSS: Baseline Characteristics

16 GAUSS: Effect of AMG 145 on Percentage Change in LDL-C From Baseline

17 GAUSS: Percentage of Patients Achieving LDL-C Goals

18 SAR236553 in Patients With Heterozygous FH on Statin Therapy With or Without Ezetimibe─Phase 2

19 SAR236553: Change in LDL-C in Patients With Heterozygous FH on Statin Therapy With or Without Ezetimibe

20 RUTHERFORD: Phase 2 AMG 145 in Patients With Heterozygous FH

21 RUTHERFORD: Effect of AMG 145 on Percentage Change in LDL-C From Baseline

22 AMG 145: Ongoing Phase 2 Trials

23 SAR236553 on Top of Atorvastatin in Primary Hypercholesterolemia: Phase 2

24 Intravenous RN316 in Hypercholesterolemic Patients on High or Maximum-Dose Statin Therapy: Phase 2 Studies

25 IV RN316 in Hypercholesterolemic Patients on High- or Maximum-Dose Statin Therapy: Doses Studied

26 Intravenous RN316 in Hypercholesterolemic Patients on High- or Maximum-Dose Statin Therapy: Pooled Results

27 ODYSSEY Outcomes: Phase 3 Post-ACS With SAR236553

28 Program Summary

29 Thank you for participating in this activity.


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