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Current and Future Perspectives on Migraine Prevention Therapy

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Presentation on theme: "Current and Future Perspectives on Migraine Prevention Therapy"— Presentation transcript:

1 Current and Future Perspectives on Migraine Prevention Therapy

2 Program Overview

3 Characteristics of Migraine

4 Current Migraine Prevention Treatment

5 Adherence to Migraine Prevention Treatment

6 Medication Overuse Headache: EFNS Headache Panel Guideline

7 CGRP Elevation in Migraine Attacks

8 Release of Perivascular Neuropeptides During Acute Primary Headache Attacks

9 CGRP Receptor Mechanisms

10 Acute Treatment With CGRP Receptor Blockers and Migraine Headache Relief

11 Effect of CGRP mAbs on Episodic Migraine: Phase 2 Trials with Different Populations and Regimens

12 50% Responder Rate in Phase 2 Trial of AMG334

13 Monoclonal Antibodies Targeting the CGRP Pathway

14 Findings for CGRP in SAH

15 Adverse Events With CGRP mAbs in Phase 2 Studies

16 CGRP, the Trigeminal Ganglion, and the Blood Brain Barrier

17 Other Areas for Research

18 Concluding Remarks

19 Abbreviations


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