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Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant.

Published byMaria da Assunção Vilanova Silva Modified over 5 years ago

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Presentation on theme: "Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant."— Presentation transcript:

1 Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research  Sally Arai, Mukta Arora, Tao Wang, Stephen R. Spellman, Wensheng He, Daniel R. Couriel, Alvaro Urbano-Ispizua, Corey S. Cutler, Andrea A. Bacigalupo, Minoo Battiwalla, Mary E. Flowers, Mark B. Juckett, Stephanie J. Lee, Alison W. Loren, Thomas R. Klumpp, Susan E. Prockup, Olle T.H. Ringdén, Bipin N. Savani, Gérard Socié, Kirk R. Schultz, Thomas Spitzer, Takanori Teshima, Christopher N. Bredeson, David A. Jacobsohn, Robert J. Hayashi, William R. Drobyski, Haydar A. Frangoul, Görgün Akpek, Vincent T. Ho, Victor A. Lewis, Robert Peter Gale, John Koreth, Nelson J. Chao, Mahmoud D. Aljurf, Brenda W. Cooper, Mary J. Laughlin, Jack W. Hsu, Peiman Hematti, Leo F. Verdonck, Melhelm M. Solh, Maxim Norkin, Vijay Reddy, Rodrigo Martino, Shahinaz Gadalla, Jenna D. Goldberg, Philip L. McCarthy, José A. Pérez-Simón, Nandita Khera, Ian D. Lewis, Yoshiko Atsuta, Richard F. Olsson, Wael Saber, Edmund K. Waller, Didier Blaise, Joseph A. Pidala, Paul J. Martin, Prakash Satwani, Martin Bornhäuser, Yoshihiro Inamoto, Daniel J. Weisdorf, Mary M. Horowitz, Steven Z. Pavletic  Biology of Blood and Marrow Transplantation  Volume 21, Issue 2, Pages (February 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 In the multivariate analysis, higher risk of cGVHD in the most recent time period ( versus : OR = 1.19, P < .0001; and versus : OR = 1.13, P = .002). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Increased cGVHD incidence when stratified by (A) donor type (HLA identical sibling: HR = 1.17; unrelated donor: HR = 1.07; cord blood: HR = 1.24, all P < .01), (B) graft type (PBSC: HR = 1.19; cord blood: HR = 1.24, P < .01), or (C) conditioning intensity (myeloablative: HR = 1.13; reduced intensity: HR = 1.16, P < .01). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

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