Presentation is loading. Please wait.

Presentation is loading. Please wait.

The Henry Ford Production System: LEAN Process Redesign Improves Service in the Molecular Diagnostic Laboratory  Milena Cankovic, Ruan C. Varney, Lisa.

Published byEleanore Greene Modified over 5 years ago

Similar presentations

Presentation on theme: "The Henry Ford Production System: LEAN Process Redesign Improves Service in the Molecular Diagnostic Laboratory  Milena Cankovic, Ruan C. Varney, Lisa."— Presentation transcript:

1 The Henry Ford Production System: LEAN Process Redesign Improves Service in the Molecular Diagnostic Laboratory  Milena Cankovic, Ruan C. Varney, Lisa Whiteley, Ron Brown, Rita D'Angelo, Dhananjay Chitale, Richard J. Zarbo  The Journal of Molecular Diagnostics  Volume 11, Issue 5, Pages (September 2009) DOI: /jmoldx Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Process map for tissue-based molecular testing: phase I (wasteful phase)—baseline measurements were defined and establishing customer- supplier relationships were established; phase II (leaner phase)—LEAN process improvements were implemented across different disciplines; phase III (leanest phase)—several “Rapid Process Improvement” modifications were added to the initial LEAN work flow to further increase efficiency. LEAN process improvements in histology and molecular pathology resulted in creation of a unidirectional work flow, greatly reduced testing times, and elimination of extra steps. The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 Comparison of regional laboratory specimen volumes. Baseline measurements were performed for 12 months, January to December 2007, and 28 blood specimens were received during that time period. Follow-up measurement was done for 5 months, March to July 2008 (a total of 69 blood specimens were received). The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 Quarterly average testing turnaround times in the molecular pathology laboratory in These TATs are estimations of average times (in business days) from the time a testing request was received until results were ready for signing out. KRAS, KRAS mutation detection; TRANS, quantitative RT-PCR assays for detection of t(9;22) and t(15;17) translocations; LOH, 1p/19q loss of heterozygosity; MGMT, MGMT promoter methylation detection; EGFR, epidermal growth factor receptor exon 19 and exon 21 mutation detection; JAK2, JAK2 mutation detection; BCGR, B-cell (IgH) gene rearrangement; TCGR, T-cell receptor γ gene rearrangement. The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Download ppt "The Henry Ford Production System: LEAN Process Redesign Improves Service in the Molecular Diagnostic Laboratory  Milena Cankovic, Ruan C. Varney, Lisa."

Similar presentations

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.
Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,

Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,
CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Accurate Molecular Characterization of Formalin-Fixed, Paraffin-Embedded Tissues by microRNA Expression Profiling Anna E. Szafranska, Timothy S. Davison,

Accurate Molecular Characterization of Formalin-Fixed, Paraffin-Embedded Tissues by microRNA Expression Profiling Anna E. Szafranska, Timothy S. Davison,
EGFR Mutations in Lung Adenocarcinomas

EGFR Mutations in Lung Adenocarcinomas
Detection of Exon 12 Mutations in the JAK2 Gene

Detection of Exon 12 Mutations in the JAK2 Gene
The Role of MGMT Testing in Clinical Practice

The Role of MGMT Testing in Clinical Practice
Detection of Low-Level KRAS Mutations Using PNA-Mediated Asymmetric PCR Clamping and Melting Curve Analysis with Unlabeled Probes  Ji Eun Oh, Hee Sun.

Detection of Low-Level KRAS Mutations Using PNA-Mediated Asymmetric PCR Clamping and Melting Curve Analysis with Unlabeled Probes  Ji Eun Oh, Hee Sun.
Toward Universal Flavivirus Identification by Mass Cataloging

Toward Universal Flavivirus Identification by Mass Cataloging
Laboratory Guidelines for Detection, Interpretation, and Reporting of Maternal Cell Contamination in Prenatal Analyses  Narasimhan Nagan, Nicole E. Faulkner,

Laboratory Guidelines for Detection, Interpretation, and Reporting of Maternal Cell Contamination in Prenatal Analyses  Narasimhan Nagan, Nicole E. Faulkner,
Screening for Mutations in Kidney-Related Genes Using SURVEYOR Nuclease for Cleavage at Heteroduplex Mismatches  Konstantinos Voskarides, Constantinos.

Screening for Mutations in Kidney-Related Genes Using SURVEYOR Nuclease for Cleavage at Heteroduplex Mismatches  Konstantinos Voskarides, Constantinos.
Kirby Siemering, Shehnaaz S. M. Manji, Wendy M

Kirby Siemering, Shehnaaz S. M. Manji, Wendy M
Quantitative Fluorescence in Situ Hybridization and its Ability to Predict Bladder Cancer Recurrence and Progression to Muscle-Invasive Bladder Cancer 

Quantitative Fluorescence in Situ Hybridization and its Ability to Predict Bladder Cancer Recurrence and Progression to Muscle-Invasive Bladder Cancer 
Comparison of BIOMED-2 Versus Laboratory-Developed Polymerase Chain Reaction Assays for Detecting T-Cell Receptor-γ Gene Rearrangements  Keyur P. Patel,

Comparison of BIOMED-2 Versus Laboratory-Developed Polymerase Chain Reaction Assays for Detecting T-Cell Receptor-γ Gene Rearrangements  Keyur P. Patel,
High Quality Assessment of DNA Methylation in Archival Tissues from Colorectal Cancer Patients Using Quantitative High-Resolution Melting Analysis  Marija.

High Quality Assessment of DNA Methylation in Archival Tissues from Colorectal Cancer Patients Using Quantitative High-Resolution Melting Analysis  Marija.
A DNA Real-Time Quantitative PCR Method Suitable for Routine Monitoring of Low Levels of Minimal Residual Disease in Chronic Myeloid Leukemia  Paul A.

A DNA Real-Time Quantitative PCR Method Suitable for Routine Monitoring of Low Levels of Minimal Residual Disease in Chronic Myeloid Leukemia  Paul A.
Wanlong Ma, Hagop Kantarjian, Xi Zhang, Chen-Hsiung Yeh, Zhong J

Wanlong Ma, Hagop Kantarjian, Xi Zhang, Chen-Hsiung Yeh, Zhong J
Mutation Screening in Juvenile Polyposis Syndrome

Mutation Screening in Juvenile Polyposis Syndrome
Detection of Cytomegalovirus in Whole Blood Using Three Different Real-Time PCR Chemistries  Erica Vincent, Zhengming Gu, Markus Morgenstern, Candace.

Detection of Cytomegalovirus in Whole Blood Using Three Different Real-Time PCR Chemistries  Erica Vincent, Zhengming Gu, Markus Morgenstern, Candace.

Similar presentations

Ads by Google