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Does compliance mismatch alone cause neointimal hyperplasia?

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Presentation on theme: "Does compliance mismatch alone cause neointimal hyperplasia?"— Presentation transcript:

1 Does compliance mismatch alone cause neointimal hyperplasia?
Steven P. Okuhn, MD, Daniel P. Connelly, MD, Nicole Calakos, BA, Linda Ferrell, MD, Pan Man-Xiang, MD, Jerry Goldstone, MD  Journal of Vascular Surgery  Volume 9, Issue 1, Pages (January 1989) DOI: / (89) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Schematic of experimental design. Note IA probe inserted through PTFE sidearm and positioned within 3 cm noncompliant banded segment. Journal of Vascular Surgery 1989 9, 35-45DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Typical multichannel recorder output at mean arterial pressure of 100 mm Hg pre (A) and post (B) banding. Note change from normal IA probe deflection to 0 probe deflection, indicating postbanding compliance fixed at 0. Journal of Vascular Surgery 1989 9, 35-45DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 A, IA probe calibration scale. B, Computer-generated regression line of the scale in A used to calculate mean arterial diameter and systolic and diastolic diameters. y = e−2x r2 = Journal of Vascular Surgery 1989 9, 35-45DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 A, Transverse section of banded artery shows absence of intimal hyperplasia. Lumen (L) is at top and space occupied by band (B) at bottom. Note fibrous reaction (open arrow) without significant inflammation and patent vasa vasora (solid arrow). (Hematoxylin and eosin stain; original magnification × 32.) B, Higher magnification of A. Note scattered red blood cells in lumen (L), absence of intimal hyperplasia, and internal elastic lamina immediately adjacent to lumen. (Hematoxylin and eosin stain; original magnification × 160.) Journal of Vascular Surgery 1989 9, 35-45DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 A, Banded segment of artery shows focal intimal hyperplasia (arrow). A segment of fibrous capsule surrounding the band is present in upper right. (Hematoxylin and eosin stain; original magnification × 50.) B, Higher magnification of A shows thickened intima composed of spindle cells. The internal elastic lamina is intact, separating intima from media. (Hematoxylin and eosin stain; original magnification × 125.) C, Nonbanded segment of control shows focal intimal hyperplasia (arrow). (Hematoxylin and eosin stain; original magnification × 50.) D, Higher magnification of C shows thickened intima and internal elastic lamina separating intima and media. (Hematoxylin and eosin stain; original magnification × 125.) Journal of Vascular Surgery 1989 9, 35-45DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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