1. Gene expression profiles as measured by the NanoString nCounter System in 54 patients with metastatic gastric cancer (GC).
Gene expression profiles as measured by the NanoString nCounter System in 54 patients with metastatic gastric cancer (GC). (A) Unsupervised hierarchical clustering of 95 differentially expressed genes in Signature I GC subtypes (mesenchymal, metabolic and proliferative). The colour bar and Cl at the top denotes clusters of GC subtypes, Cl 1 (mesenchymal), Cl 2 (metabolic), Cl 3 (mixed (mesenchymal and proliferative)) and Cl 4 (proliferative). Genes representing these regions in the heat map are shown on the right prefixed with mesen-mesenchymal, metab-metabolic and prol-proliferative. Each column represents one GC sample with red=upregulated, green=downregulated and black=unknown. (B) Unsupervised hierarchical clustering of 100 differentially expressed genes in Signature II showing GC subtypes (G-INT and G-DIF). The colour bar and Cl at the top denotes clusters of GC subtypes, Cl 1 (G-DIF), Cl 2 (mixed) and Cl 3 (G-INT). Each column represents one GC sample with red=upregulated, green=downregulated and black=unknown.
Kakoli Das et al. ESMO Open 2016;1:e000009
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