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Patient–prosthesis mismatch after transapical aortic valve implantation: Incidence and impact on survival  Marian Kukucka, MD, Miralem Pasic, MD, PhD,

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Presentation on theme: "Patient–prosthesis mismatch after transapical aortic valve implantation: Incidence and impact on survival  Marian Kukucka, MD, Miralem Pasic, MD, PhD,"— Presentation transcript:

1 Patient–prosthesis mismatch after transapical aortic valve implantation: Incidence and impact on survival  Marian Kukucka, MD, Miralem Pasic, MD, PhD, Stephan Dreysse, MD, Alexander Mladenow, MD, Helmut Habazettl, MD, PhD, Roland Hetzer, MD, PhD, Axel Unbehaun, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 145, Issue 2, Pages (February 2013) DOI: /j.jtcvs Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Kaplan-Meier survival curves for patients without P-PM (iEOA > 0.85), with moderate P-PM (iEOA ), and with severe P-PM (iEOA < 0.65). Censored patients are represented by vertical marks. Only severe P-PM was associated with increased early mortality within the first 3 months after TAVI. This effect was confirmed in a multivariate analysis. The difference in survivals persisted for 1 year and leveled off thereafter. P values were derived from the log–rank test nd all pairwise comparisons by Holm-Sidak (adjusted P = .0014 and .009 for severe versus no and moderate P-PM at 3 months and .037 and .13 at 12 month, respectively). P-PM, Patient–prosthesis mismatch; iEOA, indexed effective orifice area; TAVI, transcatheter aortic valve implantation. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Kaplan-Meier survival curves for patients with ejection fraction (EF) greater than 50% versus less than 50% (left panel) and for patients with left ventricular end-systolic volume (LVESV) less than 35 mL versus greater than 35 mL (right panel). Cutoff values for risk stratification were selected from receiver operating characteristics curves. Censored patients are represented by vertical marks. P values were derived from log–rank tests. The association of EF and LVESV with survival was, however, not confirmed in the multivariate analysis. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

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