1. Comparative Genomic Hybridization Analysis of Astrocytomas
Rodney N. Wiltshire, James E. Herndon, Annie Lloyd, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner, Roger E. McLendon 
The Journal of Molecular Diagnostics 
Volume 6, Issue 3, Pages (August 2004)
DOI: /S (10)
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2. Figure 1
Composite of CGH alterations detected in 10 World Health Organization Grade I astrocytomas. Each line denotes the chromosome regions lost (left) or gain (right) in a single case.
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3. Figure 2
Composite of CGH alterations detected in 10 World Health Organization Grade II astrocytomas. Each line denotes the chromosome regions lost (left) or gain (right) in a single case.
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4. Figure 3
Composite of CGH alterations detected in 26 anaplastic astrocytomas (World Health Organization Grade III). Each line denotes the chromosome regions lost (left) or gain (right) in a single case. Thick lines illustrate regions with high-level gains. Brackets depict the smallest region of consistent overlap on chromosomes with statistically significant copy number changes.
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

5. Figure 4
Composite of CGH alterations detected in (A) 25 progressive and (B) 31 de novo glioblastoma multiforme (World Health Organization Grade IV). Each line denotes the chromosome regions lost (left) or gain (right) in a single case. Thick lines illustrate regions with high-level gains. Brackets depict the smallest region of consistent overlap on chromosomes with statistically significant copy number changes.
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

6. Figure 5
Representative FISH analyses for the verification of chromosome 19 over-representation detected by CGH. A: An example of the FISH analysis on case GBM-39, whose accompanying CGH profile demonstrates a high-level gain (CGH ratio >1.45) on chromosome 19. B: An example of the FISH on case GBM-25 whose accompanying CGH profile shows a simple gain of 19p (CGH ratio = 1.20) and a normal diploid complement (CGH ratio = 1.0) of 19q. Hybridizations of the 19p (green signals) and 19q (red signals) telomeric probes, and the chromosome 18 centromeric probe (aqua blue signal) are shown in the left panels. The corresponding CGH profiles for chromosome 19 are shown in the right panels. The CGH profile ratio thresholds representing a normal diploid complement, loss, and gain of DNA sequences are indicated by the black line (ratio 1.0), red line (ratio 0.85), and the green line (ratio 1.20), respectively.
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

7. Figure 6
Kaplan-Meier plots depicting the effect of CGH alterations on the survival of astrocytoma patients determined by a univariate analysis using the Cox proportional hazards model. Patients with the CGH alterations (dotted lines), (A) gain of 7q (P < ) and (B) loss of 10q (P = 0.004) showed a significant reduction in survival compared to patients without these alterations (solid lines).
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

8. Figure 7
Kaplan-Meier plots illustrating the effect of the accumulation of CGH alterations on patient survival. A: AA and GBM patients with CGH alterations + 7p, +7q, −10p, and −10q (broken lines) compared to those without these CGH alterations (solid line). B: GBM patients with CGH alterations + 7p, +7q, −10p, −10q, +19p, +19q, +20p, and +20q (broken lines) compared to those without these CGH alterations (solid line).
The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) )
Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions