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South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin 

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Presentation on theme: "South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin "— Presentation transcript:

1 South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin  Fatemah Thawer-Esmail, MD, FCDermSA, Ivone Jakasa, PhD, Gail Todd, FFDerm (SA), PhD, Yaran Wen, PhD, Sara J. Brown, MD, Karin Kroboth, MSc, Linda E. Campbell, BSc, Grainne M. O'Regan, MRCPI, W.H. Irwin McLean, DSc, FMedSci, Alan D. Irvine, MD, Sanja Kezic, PhD, Aileen Sandilands, PhD  Journal of Allergy and Clinical Immunology  Volume 133, Issue 1, Pages e2 (January 2014) DOI: /j.jaci Copyright © 2013 The Authors Terms and Conditions

2 Fig 1 Levels of filaggrin degradation products in the SC of healthy controls (Ctrl, n = 81) and patients with AD (n = 69) (median with interquartiles). FAA + derivatives, FAA including UCA, PCA, citrulline, and ornithine. ***P < .001 as determined by the 2-tailed Wilcoxon-Mann-Whitney test. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

3 Fig E1 Amino acid composition of filaggrin. Ala, Alanine; Arg, arginine; Asn, asparagine; Asp, aspartate; Cys, cysteine; Gln, glutamine; Glu, glutamate; Gly, glycine; His, histidine; Ile, isoleucine; Leu, leucine; Lys, lysine; Met, methionine; Phe, phenylalanine; Pro, proline; Ser, serine; Thr, threonine; Trp, tryptophan; Tyr, tyrosine; Val, valine. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions


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