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Introduction to IV Admixture and Aseptic Technique

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Presentation on theme: "Introduction to IV Admixture and Aseptic Technique"— Presentation transcript:

1 Introduction to IV Admixture and Aseptic Technique
Pharmacy 721 January 23-27, 2006

2 Objectives Background and Definitions Equipment USP 797 Technique

3 Background Parenteral: injected through skin or other external boundary tissue, “alongside of” “small intestine” Uses: NPO – nothing by mouth Unstable in GI, 1st pass metabolism Immediate action needed Delivery to specific site Depot form

4 Definitions LVP-large volume parenteral (>100 ml)
“piggy back” – smaller volume (may be up to 250 ml) D5W (5% dextrose in water) NS (normal saline) 0.9%NaCl Compounded Sterile Preparation (CSP) Continuous infusion vs. intermittent dosing

5 Definitions HEPA filter- High Efficiency Particulate Air
0.3 micron, 99.97% ISO: International Organization for Standardization ISO 5: Clean room standards based on particles for cubic meter by particle size Class 100: number of particles ≥ 5 μm per cubic foot

6 Hood types Horizontal Laminar Airflow Workbench

7 Hood Types Vertical Laminar Airflow Workbench (Biosafety)

8 Hood Types Barrier Isolator

9 USP 797 Risk Levels High (3) Medium (2) Low (1)
Nonsterile ingredients <ISO class 5 24 hours rt, 3 days cold Medium (2) Multiple doses Complex manipulations 30 hours rt, 7 days cold Low (1) Sterile components ISO Class 5 <3 sterile products See Tables 32.1 and 32.2 in Thompson

10 Clean room Video

11 Syringes and Needles Parts of syringe (32.12) Parts of needle (32.12)
Barrel Plunger Tip Parts of needle (32.12) Bevel Shaft Hub

12 Injection technique Critical sites Swabbing Bevel up, angle
Equalize pressure

13 IV Preparation Preparation Cleaning Inspection Manipulation
Calculations Assembly Cleaning Inspection Expiration dates Quality Manipulation

14 References and Resources
USP, Proposed Revisions to USP Chapter <797> ASHP Self Assessment Tool for Compounding Sterile Preparations Ockerman AV, U.S. Pharmacist, Compounded Sterile Preparations: An Overview of the New Standards USP <797> ASHP Guidelines on Quality Assurance for Pharmacy-Prepared Sterile Products, Am J Health-Syst Pharm, 2000;57:

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