1. Characterization of antibody response in neuroinvasive infection caused by Toscana virus 
A. Pierro, S. Ficarelli, N. Ayhan, S. Morini, L. Raumer, M. Bartoletti, A. Mastroianni, F. Prati, S. Schivazappa, P. Cenni, C. Vocale, G. Rossini, P. Gaibani, V. Sambri, M.P. Landini, R.E. Lewis, R.N. Charrel, S. Varani 
Clinical Microbiology and Infection 
Volume 23, Issue 11, Pages (November 2017)
DOI: /j.cmi
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2. Fig. 1
Specific antibody development in TOSV infected patients. Anti-TOSV IgM (a) and IgG (b) antibody development in 41 patients with acute TOSV infection is represented in box-and-whisker plots. Log10 IgG median and interquartile range; vertical lines represent minimum and maximum values. ND, not detected.
Clinical Microbiology and Infection  , DOI: ( /j.cmi )
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3. Fig. 2
TOSV-IgG avidity index (AI). Maturation of anti-TOSV IgG during the 600 days of study. The AI increased over the first month of infection until a plateau by Day 180, then decreased to low values by Day 600. Data points represent median values plus 95% CI for median.
Clinical Microbiology and Infection  , DOI: ( /j.cmi )
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4. Fig. 3
TOSV IgG maturation. AI was not influenced by patients' gender (a) and age (b), but was higher in patients with meningoencephalitis at Day 30 and Day 90 post infection (c). Data points represent median values plus 95% CI for median.
Clinical Microbiology and Infection  , DOI: ( /j.cmi )
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

5. Fig. 4
TOSV neutralization assay. 210 sera were tested for TOSV MN assay and 187 were TOSV reactive with moderate neutralizing titre. Log10 median and interquartile range; vertical lines represent minimum and maximum values.
Clinical Microbiology and Infection  , DOI: ( /j.cmi )
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

6. Fig. S1. Specific IgM and IgG titre is not dependent on age, gender, or disease severity in TOSV infected patients. Anti-TOSV IgM (a, c, e) and IgG (b, d, f) antibody titres in 41 patients with acute TOSV infection segregated on the basis of age (a, b), gender (c, d), and disease severity (e, f). IgG median±95% CI.
Clinical Microbiology and Infection  , DOI: ( /j.cmi )
Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions