1. Understanding Immunosuppression after Sepsis
Fatemeh Fattahi, Peter A. Ward 
Immunity 
Volume 47, Issue 1, Pages 3-5 (July 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Disordered Innate Immune Pathways after Sepsis or Trauma
Bacterial pneumonia or trauma leads to sepsis with several imbalances in innate immune pathways. Both DCs and macrophages exhibit reduced ability to process antigen, and the afflicted tissue exhibits an accumulation of Treg cells and high amounts of the immunosuppressive cytokine TGFβ. The impaired function of DCs is associated with the reduced expression of the transcription factor IRF4 and the increased expression of the Blimp1. Collectively, these events results in protracted immunosuppression and defective ability to handle subsequent bacterial challenges.
Immunity  , 3-5DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions