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Atsunari Tsuchisaka, Minao Furumura, Takashi Hashimoto 

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1 Cytokine Regulation during Epidermal Differentiation and Barrier Formation 
Atsunari Tsuchisaka, Minao Furumura, Takashi Hashimoto  Journal of Investigative Dermatology  Volume 134, Issue 5, Pages (May 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Schematic diagram of four layers of the epidermis, expression profiles of keratins, filaggrin, and desmosomal and tight junction proteins, five terminal differentiation processes, and regulation by cytokines. Left panel shows four distinct epidermal layers and expression patterns of four keratins, filaggrin, four Dsgs, three Dscs, corneodesmosin, and tight junction proteins. Right panel shows detailed information for five distinct epidermal differentiation processes, as well as various cytokines, which upregulate or downregulate the epidermal differentiation. IL-4 and IL-13 are shown in red-colored letters. The left panel was adapted from the figure in the reference of Simpson et al. (2011), and the right panel was adapted from figures in the reference of Hänel et al. (2013) and Gutowska-Owsiak and Ogg (2013). Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Journal of Investigative Dermatology 2014 134, 1194-1196DOI: (10
Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions


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