1. PCORI Research Priorities and Relevant Examples
Anne Trontell, MD, MPH
Associate Director, Clinical Effectiveness and Decision Sciences
Patient-Centered Outcomes Research Institute
Women’s Health Technologies CRN Annual Meeting
FDA White Oak Campus in Silver Spring
September 7, 2018

2. Conflicts of Interest/Disclaimer
No conflicts to disclose
Statements and opinions are mine alone and should not be attributed as the opinions, practices, or policies of the Patient Centered Outcomes Research Institute

3. PCORI’s Approach to Research
An independent, non-profit research institute supporting comparative effectiveness research to address multi-stakeholder questions about health care choices
Focus on patient-centered outcomes in comparing the clinical effectiveness of 2 or more options to care for a clinical condition or to improve health care delivery
Research done in real-world populations and settings with attention to subgroup differences
Engagement of patients and other stakeholders throughout the research process
National Research Priorities established with input from PCORI Board of Governors & Methodology committee, as well as patients, other stakeholders, and open public comments
Bolded text shows how PCORI’s trial fit the NIH definition of pragmatic trials

4. PCORI National Priorities for Research
Assessment of Prevention, Diagnosis, and Treatment Options
Research that:
Compares the effectiveness and safety of alternative prevention, diagnosis, and treatment options
Determines which options work best overall and for different subgroups of patients
Examples

5. PCORI National Priorities for Research
Assessment of Prevention, Diagnosis, and Treatment Options
Research that:
Compares a variety of health system-level approaches to optimize the quality, outcomes, and efficiency of patient care
System levels include patients, families, providers, care teams, organizations, practice settings, delivery options, or policies
Examples: Innovative use of health information technology, care coordination for complex conditions, and effective workforce deployment
Improving Healthcare Systems

6. PCORI National Priorities for Research
Assessment of Prevention, Diagnosis, and Treatment Options
Improving Healthcare Systems
Research on:
Effective ways to provider information produced by CER
Empowering people to ask for and use the information
Supporting shared decision making between patients and their providers
Communication and Dissemination Research

7. PCORI National Priorities for Research
Assessment of Prevention, Diagnosis, and Treatment Options
Improving Healthcare Systems
Research on:
Reduction or elimination of disparities in health or health care
Prevention, diagnosis, or treatment effectiveness AND health care system interventions to reduce barriers or identify best practices
Healthcare required to achieve best outcomes in each population
Communication and Dissemination Research
Addressing Disparities

8. PCORI National Priorities for Research
Assessment of Prevention, Diagnosis, and Treatment Options
Improving Healthcare Systems
Research on:
Building data infrastructure (PCORnet)
Determining best methods of current approaches such as registries
Improving analytic methods
Training researchers, patients, and other stakeholders in how to participate in comparative effectiveness research
Communication and Dissemination Research
Addressing Disparities
Accelerating Patient-Centered Outcomes Research and Methodological Research

9. PCORI Research Investments

10. Questions
Anne Trontell, MD, MPH