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Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training  S.G. Petersen, T. Saxne, D. Heinegard,

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Presentation on theme: "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training  S.G. Petersen, T. Saxne, D. Heinegard,"— Presentation transcript:

1 Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training  S.G. Petersen, T. Saxne, D. Heinegard, M. Hansen, L. Holm, S. Koskinen, C. Stordal, H. Christensen, P. Aagaard, M. Kjaer  Osteoarthritis and Cartilage  Volume 18, Issue 1, Pages (January 2010) DOI: /j.joca Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Time-schedule. Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Progress of participants throughout the trial.
Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 Leg-press 5 RM tests. All groups increased significantly in strength (***P≤0.001). Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 Knee extension 5 RM tests. All groups increased significantly in strength (**P≤0.01, ***P≤0.001). Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

6 Fig. 5 Levels of serum COMP (on a logarithmic scale) pre and post 12-week of strength training. Each line represents an individual patient. We observed a statistical significant decrease in serum COMP levels in the glucosamine-group (P=0.012). Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

7 Fig. 6 Urine CTX-II levels (on a logarithmic scale) pre and post 12-weeks strength training. Each line represents an individual patient. No significant alterations in CTX levels were observed in any of the groups. Osteoarthritis and Cartilage  , 34-40DOI: ( /j.joca ) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions


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