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Neuronal Growth and Death: Order and Disorder in the Axoplasm

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1 Neuronal Growth and Death: Order and Disorder in the Axoplasm
Don W Cleveland  Cell  Volume 84, Issue 5, Pages (March 1996) DOI: /S (00)

2 Figure 1 Structure of Axoplasm
(A) Schematic representation of the structural features and asymmetry of a human motor neuron. The enlarged portion shows neurofilament arrays in the ∼10 μm diameter segments (internodes) myelinated by single Schwann cells and in the 1 μm diameter unmyelinated segments (nodes). Phosphorylation of tail domains of NF-M and NF-H is restricted to myelinated segments. (B) Quick freeze, deep etch view of the cytoplasm of a myelinated axon from rat sciatic nerve. A single (25 nm) microtubule, with two vesicles that are probably moving along it, is seen in the center; all the remaining filaments (∼10 nm) are neurofilaments. Bar, 100 μm. (Micrograph kindly provided by N. Hirokawa.) (C) Rotary shadowed view of a native neurofilament showing the tail domains of NF-M and NF-H extending from the core of the filament. Bar, 100 μm. (Micrograph kindly provided by U. Aebi.) Cell  , DOI: ( /S (00) )

3 Figure 2 Model of Motor Neuron Degeneration and Death Caused by Blockage of Axonal Transport See text for details. Cell  , DOI: ( /S (00) )


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