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Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas  Dennis J. Shusterman, MD,

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Presentation on theme: "Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas  Dennis J. Shusterman, MD,"— Presentation transcript:

1 Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas  Dennis J. Shusterman, MD, MPH a, Mary Alice Murphy, MD, MPH b, John R. Balmes, MDa  Journal of Allergy and Clinical Immunology  Volume 101, Issue 6, Pages (June 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Overall study design for chlorine provocation. Study was counterbalanced with respect to both gender and order of exposure (i.e., equal numbers of male and female rhinitic and nonrhinitic subjects were exposed to air or chlorine first). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Schematic of chlorine dilution apparatus. Note that exposure was by nasal mask with scavenger hose attached to T-piece, allowing subject to transition from exposure to physiologic testing without leaving climate-controlled chamber. CPAP, Continuous positive airway pressure. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Net percent change in nasal airway resistance (from baseline) ± SEM (chlorine minus air condition) for postexposure times 1 and 2 by rhinitis status (p < 0.05 by ANOVA at both testing times). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Paired analyses of percent change in nasal airway resistance (from baseline) stratified by rhinitis status and time ( p < 0.05 by paired t test for rhinitic subjects only at both testing times). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

6 Fig. 5 Symptom ratings by time stratified by rhinitis status (1 = slight and 2 = moderate). Significant elevations were apparent, comparing chlorine and air exposures, for odor intensity (p < 0.01 at end of exposure for rhinitic subjects and p < 0.05 for nonrhinitic subjects), nasal irritation (p < 0.05 at end of exposure for rhinitic subjects only), and nasal congestion (p < 0.05 at 15 minutes after exposure for rhinitic subjects only). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

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