1. Viral genomes and Eukaryotic Virus Growth

5. Figure 6.20 5

8. Picornavirus (RNA) Life Cycle
Figure 6.23 8

9. The poliovirus binds to poliovirus receptor (PVR) through its VP2 and VP3 subunits.
- A conformational change in VP1 allows insertion of the genome into the cytoplasm.
Figure 11.12 9

10. Poliovirus Replication
In the cytoplasm, the RNA is translated to make three large precursor peptides: P1–3.
- All three peptides are eventually cleaved by proteases to generate 11 proteins.
Figure 11.13A 10

11. Influenza Virus Structure
The flu virus has no geometric capsid.
RNA genome is loosely contained by a shell of matrix proteins.
Figure 11.16
RNA segments are coated with nucleocapsid proteins (NPs).
Two major envelope proteins:
- Neuraminidase (NA)
- Hemagglutinin (HA) 11

14. The Genome of Influenza A Virus
Figure 11.17 14

15. - Instant new strain can evade the immune system.
The key advantage of a segmented genome is that it facilitates recombination between two strains coinfecting the same cell.
- Instant new strain can evade the immune system.
Figure 11.18B 15

16. Figure 11.21 16

17. Reo virus
ds RNA

18. Herpes Simplex Virus Structure
An icosahedral capsid houses the dsDNA genome.
Capsid is surrounded by a protein tegument, which is contained within an envelope with spike proteins.
Figure 11.31A 18

19. Figure 11.32 19

21. Fig
tRNA-like
structure
Stop
codon
Cap
MTH
RNP MP CP

25. Figure 6-6 Viroids: infective RNA.
sfmb2e_0606.jpg

27. Figure 6-7 Prion disease.
sfmb2e_0607.jpg