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Published byDominic Singleton Modified over 5 years ago
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The predictive value for in vitro fertility delivery rates is greatly impacted by the method used to select the threshold between normal and elevated basal follicle-stimulating hormone Richard T. Scott, M.D., H.C.L.D., Karen E. Elkind-Hirsch, M.Sc., Ph.D., H.C.L.D., Allison Styne-Gross, M.D., Kathleen A. Miller, B.S., John L. Frattarelli, M.D. Fertility and Sterility Volume 89, Issue 4, Pages (April 2008) DOI: /j.fertnstert Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 (A) Delivery rates per initiated cycle for the population as a whole in relation to basal FSH levels. No live births occurred in women with basal FSH levels of ≥18.0 IU/L. (B) Live birth rates as calculated for each 1-IU/L increment of basal FSH for each of the five age groups. The live birth rate remained relatively constant over the range of relatively low basal FSH levels, with a sharp decline at the to 15.0-IU/L range. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Receiver operating characteristic curves evaluating the value of basal FSH level in predicting a failure to deliver, starting at 1 IU/L and increasing in 1-IU/L increments. The data for the population as a whole were used to create an ROC curve. The data within each of the five individual age groups also were used to create individual ROC curves for each age group. The threshold values from each group's ROC curve were then applied to their own group, and predictive values were calculated. The points most distant from baseline (blue circle) were selected as the individual thresholds, and the predictive values, by using those thresholds. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions
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Figure 3 Greater-than-efficiency curve calculations for basal FSH levels, calculated in 1-IU/L increments. Efficiency curves involve sequential calculation of the delivery rate at every possible threshold, starting at 1 IU/L and moving upward to the highest level in the population. Efficiency curves were calculated for each of the five age groups. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions
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