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Matthieu Desroses, Mikael Altun  Cell Chemical Biology 

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Presentation on theme: "Matthieu Desroses, Mikael Altun  Cell Chemical Biology "— Presentation transcript:

1 The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition 
Matthieu Desroses, Mikael Altun  Cell Chemical Biology  Volume 24, Issue 12, Pages (December 2017) DOI: /j.chembiol Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Figure 1 Chemical Structures of Selected USP7 Inhibitors
Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2017 Elsevier Ltd Terms and Conditions

3 Figure 2 Schematic Illustration of the Apo-structure of USP7’s Catalytic Domain (PDB 1NB8) Having Its Catalytic Triad Misaligned before Ubiquitin Binding (PDB 1UBI) and Aligned upon Binding of Ubiquitin (PDB 1NBF) Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2017 Elsevier Ltd Terms and Conditions

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