1. A Stumper: How Much Spent for How Much Prevention?
From the Publishers of
Consult Guys
A Stumper: How Much Spent for How Much Prevention?
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3. Today’s Stumper
What health care product’s benefit was first reported in 1977?

4. Hints
Annual sales of the product in 2014 were estimated at $1.15 billion.
It is estimated that by 2025, annual sales will be $3.69 billion.
It is most often used in the prevention of cardiovascular disease.
There is no evidence that it has any effect on cardiovascular disease.

5. Fish Oil

6. Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;2: [PMID: 89498].

7. Hemostatic function and platelet polyunsaturated fatty acids in Eskimos
Eskimos have a bleeding tendency
Eskimos had decreased platelet aggregation
They have a low incidence of cardiovascular disease
Their diet rich in fish oil may be the explanation
Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;2: [PMID: 89498].

8. 2012: No cardiovascular benefit
Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation
and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308:
[PMID: ] doi: /2012.jama.11374

9. 2018: Still no cardiovascular benefit
Aung T, Halsey J, Kromhout D, Gerstein HC, Marchioli R, Tavazzi L, et al; Omega-3 Treatment Trialists’ Collaboration. Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving individuals. JAMA Cardiol. 2018;3: [PMID: ] doi: /jamacardio

10. Asbell PA, Maguire MG, Pistilli M, Ying GS, Szczotka-Flynn LB, Hardten DR, et al; Dry Eye Assessment and Management
Study Research Group. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med.
2018;378: [PMID: ] doi: /NEJMoa170969

11. Fish Oil No Better Than Placebo
Asbell PA, Maguire MG, Pistilli M, Ying GS, Szczotka-Flynn LB, Hardten DR, et al; Dry Eye Assessment and Management
Study Research Group. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med.
2018;378: [PMID: ] doi: /NEJMoa170969

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