Presentation is loading. Please wait.

Presentation is loading. Please wait.

Differences in human gingival and dermal fibroblasts may contribute to oral-induced tolerance against nickel  Lina Gölz, MD, Elisa Vestewig, Moritz Blankart,

Published byKlaudia Brinkerhoff Modified over 5 years ago

Similar presentations

Presentation on theme: "Differences in human gingival and dermal fibroblasts may contribute to oral-induced tolerance against nickel  Lina Gölz, MD, Elisa Vestewig, Moritz Blankart,"— Presentation transcript:

1 Differences in human gingival and dermal fibroblasts may contribute to oral-induced tolerance against nickel  Lina Gölz, MD, Elisa Vestewig, Moritz Blankart, MR, Dominik Kraus, MD, Thorsten Appel, MD, Stilla Frede, PhD, Andreas Jäger, MD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 4, Pages e3 (October 2016) DOI: /j.jaci Copyright © 2016 The Authors Terms and Conditions

2 Fig 1 Altered NF-κB and HIF-1α activation. Activation of the transcription factors NF-κB (A) and HIF-1α (D) was determined followed by the analysis of mRNA and protein of their target genes IL-1β (B and C) and VEGF (E and F) in dermal (HDFs) and gingival fibroblasts (HGFs) stimulated with 100 μmol/L Ni2+. Means ± SEMs are depicted (*P < .05, **P < .01, ***P < .001). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 The Authors Terms and Conditions

3 Fig 2 IL-10 and CCL20 expression and DC migration. IL-10 (A and B) and CCL20 (C and D) mRNA and protein expression was determined in dermal (HDFs) and gingival fibroblasts (HGFs) after 100 μmol/L Ni2+ challenge (E). Induction of DC migration by supernatants of HDFs or HGFs was determined after 24 hours. Means ± SEMs are depicted (*P < .05, **P < .01, ***P < .001). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 The Authors Terms and Conditions

Download ppt "Differences in human gingival and dermal fibroblasts may contribute to oral-induced tolerance against nickel  Lina Gölz, MD, Elisa Vestewig, Moritz Blankart,"

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Immune deficiency caused by impaired expression of nuclear factor-κB essential modifier (NEMO) because of a mutation in the 5′ untranslated region of.

Immune deficiency caused by impaired expression of nuclear factor-κB essential modifier (NEMO) because of a mutation in the 5′ untranslated region of.
Modulation by aspirin of nuclear phospho–signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated.

Modulation by aspirin of nuclear phospho–signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated.
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes  Naoko Kanda, MD, PhD, Hiroshi Mitsui, MD, PhD, Shinichi.

Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes  Naoko Kanda, MD, PhD, Hiroshi Mitsui, MD, PhD, Shinichi.
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
TNF-α–induced protein 3 (A20): The immunological rheostat

TNF-α–induced protein 3 (A20): The immunological rheostat
Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8  Markus Janke, PhD, Jens Poth, Vera Wimmenauer, Thomas.

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8  Markus Janke, PhD, Jens Poth, Vera Wimmenauer, Thomas.
Practice Notes from the AAAI

Practice Notes from the AAAI
Staphylococcus aureus enhances the tight junction barrier integrity in healthy nasal tissue, but not in nasal polyps  Can Altunbulakli, MSc, Rita Costa,

Staphylococcus aureus enhances the tight junction barrier integrity in healthy nasal tissue, but not in nasal polyps  Can Altunbulakli, MSc, Rita Costa,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis  Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,

Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis  Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,
Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF- β1–stimulated primary human fibroblasts  Xiuxia Zhou, PhD, Haizhen.

Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF- β1–stimulated primary human fibroblasts  Xiuxia Zhou, PhD, Haizhen.
The Editors' Choice Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology
Culture medium from TNF-α–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms  Wenru Su, MD,

Culture medium from TNF-α–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms  Wenru Su, MD,
Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma  Po-Jui Chang, MD, Pankaj K. Bhavsar, PhD,

Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma  Po-Jui Chang, MD, Pankaj K. Bhavsar, PhD,
Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype.

Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype.
Innate immune responses of airway epithelium to house dust mite are mediated through β-glucan–dependent pathways  Amy T. Nathan, MD, Elizabeth A. Peterson,

Innate immune responses of airway epithelium to house dust mite are mediated through β-glucan–dependent pathways  Amy T. Nathan, MD, Elizabeth A. Peterson,
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages  Elena Goleva, PhD, Pia J. Hauk, MD, Clifton.

Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages  Elena Goleva, PhD, Pia J. Hauk, MD, Clifton.
Peter M. Wolfgram, MD, David B. Allen, MD 

Peter M. Wolfgram, MD, David B. Allen, MD 

Similar presentations

Ads by Google