1. Expert Debate in MDD

3. This program may include a discussion of off-label treatments not approved by the FDA for use in the United States.

4. Epidemiology of Depression

5. Assessing the Burden of Depression

6. Effect of Depression on QoL and Function: Analysis of Data From STAR*D

7. PHQ-2

8. PHQ-9

9. PDQ-5

10. THINC-It

11. Goldberg Depression Scale

12. ACE Questionnaire

13. Using Rating Scales in Clinical Practice

14. Using Rating Scales in Clinical Practice: Focus on Patient Goals

15. Augment vs Switch in Patients With Inadequate Response: Considerations

16. Augment vs Switch in Patients With Inadequate Response: STAR*D

17. Case 1: History and Initial Presentation

18. Case 1: Social and Medical History

19. Case 1: PHQ-9

20. Case 1: PDQ-5

21. Digit Symbol Substitution Test

22. Addressing Cognitive Impairment

23. Effect of Vortioxetine on Cognitive Impairment

24. Case 2: History and Assessment

25. Case 2: PHQ-9

26. Case 2: Mental Status Exam

27. Case 2: Current Diagnoses and Medications

28. Case 2: A Multidisciplinary Approach

29. Case 2: Optimizing the Therapeutic Regimen

30. The Need to Individualize Treatment

31. Conclusions

32. Abbreviations

33. Abbreviations (cont)