1. Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: a randomized, controlled study 
P. Saravanan, A.R. Exley, K. Valchanov, N.D. Casey, F. Falter 
British Journal of Anaesthesia 
Volume 103, Issue 6, Pages (December 2009)
DOI: /bja/aep297
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Changes in leucocyte and platelet counts during isolated CPB in the control and the xenon groups. Serial leucocyte (a), neutrophil (b), monocyte (c), and platelet (d) counts (in 109 litre−1) are shown plotted against time in minutes in the control and the xenon groups during isolated CPB, with normalization for haemodilution using the formula: haemoglobin concentration at baseline divided by the mean haemoglobin concentration during isolated CPB. Data are mean (sem). There is no significant difference between the groups for any parameter at any time point, P>0.05. Leucocyte counts (a) vs baseline in controls P=0.05 at 5 min, P<0.02 at 15, 30, 60, 90 min, for xenon at 5 min P=0.002, P<0.001 thereafter; vs 5 min in controls P<0.01 at 15 min, P=0.005 at 30 min, and for xenon P=0.009 and 0.04, respectively. Neutrophil counts (b) vs baseline in controls P=0.034 at 5 min, P<0.05 thereafter, for xenon P=0.005 at 5 min, P<0.005 thereafter; vs 5 min P<0.05 at 30 min in both the groups. Monocyte counts (c) vs baseline in controls P<0.05 at 5 min, P<0.01 thereafter, for xenon P<0.005 at 5 min and thereafter; vs 5 min for both the groups P<0.01 at 30 min and vs 15 min P<0.05 at 30 min. For platelet counts (d) vs baseline in controls P=0.02 at 5 min, P<0.05 at 15 min, no significant difference thereafter, for xenon P<0.001 at 5 min, P<0.01 at 15, 30 min, no significant difference thereafter; vs 5 min for both the groups P<0.001 at 30, 60, 90 min. *P<0.05 and **P<0.005 vs baseline.
British Journal of Anaesthesia  , DOI: ( /bja/aep297)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Very early changes in leucocytes and platelet counts during isolated CPB (pooled data). Serial mean neutrophil (a), monocyte (b), and platelet counts (c) (in 109 litre−1) are shown plotted against time in minutes during isolated CPB, with normalization for haemodilution. The pooled data, n=16 circuits, are shown. Paired t-test values: for neutrophil counts (a) vs baseline are P=0.001 at 5 min and P< at 15, 30, 60, 90 min; vs 5 min are P<0.005 at 15, 30, 60, 90 min; vs 15 min P<0.05 at 30 min; for monocyte counts (b) vs baseline are P< at 5, 15, 30, 60, 90 min; vs 5 min P<0.005 at 15, 30, 60, 90 min; vs 15 min P<0.001 at 30, 60, 90 min; for platelet counts (c) vs baseline are P< at 5, 15 min, P<0.01 at 30 min, and P<0.05 at 60 min; vs 5 min P<0.001 at 15, 30, 60, 90 min; vs 15 min P< at 30, 60, 90 min; vs 30 min P< at 60, 90 min. *P<0.05, **P<0.005, and ***P< vs baseline.
British Journal of Anaesthesia  , DOI: ( /bja/aep297)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Changes in inflammatory cells during isolated CPB (pooled data). Serial CD14++ monocyte (a), CD16+ monocyte (b), and total PMC (c) counts (in 106 litre−1), percentage of CD14++ monocytes complexed with platelets (d), and percentage of neutrophils complexed with platelets, PNCs, (e) are shown plotted against time in minutes during the isolated CPB. Values are corrected for haemodilution. Paired t-test values: for CD14++ monocyte counts (a) vs baseline P<0.005 at 5, 90 min, P< at 15, 30, 60 min; for CD16+ monocyte counts (b) vs baseline P=0.02 at 5 min, P<0.005 at 15, 30, 60, 90 min; for total PMCs (c) vs baseline P<0.03 at 5, 15 min, P<0.01 at 30, 60, 90 min; for %CD14++ PMCs (d) vs baseline P<0.05 at 15, 60 min; vs 15 min P<0.05 at 30 min; for %PNCs (e) vs baseline P=0.02 at 15 min, vs 5 min P<0.005 at 15 min, P<0.05 at 30, 60 min, P=0.05 at 90 min. *P<0.05, **P<0.005, and ***P< vs baseline.
British Journal of Anaesthesia  , DOI: ( /bja/aep297)
Copyright © 2009 British Journal of Anaesthesia Terms and Conditions