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IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis  Samuel Bruls, MD, Audrey Courtois, MS, PhD, Philippe Delvenne, MD, PhD,

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Presentation on theme: "IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis  Samuel Bruls, MD, Audrey Courtois, MS, PhD, Philippe Delvenne, MD, PhD,"— Presentation transcript:

1 IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis 
Samuel Bruls, MD, Audrey Courtois, MS, PhD, Philippe Delvenne, MD, PhD, Roland Hustinx, MD, PhD, Michel Moutschen, MD, PhD, Laurence De Leval, MD, PhD, Jean-Olivier Defraigne, MD, PhD, Natzi Sakalihasan, MD, PhD  The Annals of Thoracic Surgery  Volume 103, Issue 3, Pages e239-e240 (March 2017) DOI: /j.athoracsur Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 (A) Contrast-enhanced computed tomographic (CT) images showing retroperitoneal and right perirenal infiltration (arrows). (B) Positron emission tomographic / CT images showing intense 18F-fluorodeoxyglucose uptake at multiple lymph node sites and adjacent to the right renal hilum (arrows). (C) Hematoxylin and eosin staining of lymph node showing stellar fibrous patches and plasma cell infiltration. Immunoperoxidase staining for immunoglobulin G (IgG) and IgG4 showing (D) numerous IgG-positive plasma cells including (E) a high proportion of IgG4-positive cells. (C, D, and E: original magnification × 200.) The Annals of Thoracic Surgery  , e239-e240DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Pathologic examination results of excised valve leaflets showing valve leaflet infiltration by inflammatory mononuclear cells including plasma cells (left, hematoxylin and eosin [H/E]) and showing immunoreactivity for immunoglobulin G (IgG) and IgG4 (middle and right, respectively; immunoperoxidase). (left: original magnification × 100; middle: original magnification × 100; right: original magnification × 200.) The Annals of Thoracic Surgery  , e239-e240DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

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