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High Rabbit-Antihuman Thymocyte Globulin Levels Are Associated with Low Likelihood of Graft-vs-Host Disease and High Likelihood of Posttransplant Lymphoproliferative.

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Presentation on theme: "High Rabbit-Antihuman Thymocyte Globulin Levels Are Associated with Low Likelihood of Graft-vs-Host Disease and High Likelihood of Posttransplant Lymphoproliferative."— Presentation transcript:

1 High Rabbit-Antihuman Thymocyte Globulin Levels Are Associated with Low Likelihood of Graft-vs-Host Disease and High Likelihood of Posttransplant Lymphoproliferative Disorder  Peter J. Podgorny, Alejandra Ugarte-Torres, Yiping Liu, Tyler S. Williamson, James A. Russell, Jan Storek  Biology of Blood and Marrow Transplantation  Volume 16, Issue 7, Pages (July 2010) DOI: /j.bbmt Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Determination of ATG level. (A) Phycoerythrin fluorescence peaks, each corresponding to a standard ATG concentration. X-axis shows phycoerythrin fluorescence intensity area (PE-A). Y-axis shows the percent maximum cell count (of lymphocytes acquired for each ATG concentration). (B) Example of a standard curve. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 ATG levels in patients with selected clinical outcomes. Horizontal bars indicate median values. NNST indicates “not needing systemic therapy” and NST indicates “needing systemic therapy.” P-values shown are from the Mann-Whitney-Wilcoxon rank-sum test (univariate analysis). N.S. indicates nonsignificant or no trend toward significance (P > .15). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 2 ATG levels in patients with selected clinical outcomes. Horizontal bars indicate median values. NNST indicates “not needing systemic therapy” and NST indicates “needing systemic therapy.” P-values shown are from the Mann-Whitney-Wilcoxon rank-sum test (univariate analysis). N.S. indicates nonsignificant or no trend toward significance (P > .15). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 3 Cumulative incidence of grade II-IV acute GVHD, chronic GVHD NST or PTLD in patients with day 7 or 28 ATG levels above or below the cutoff specified in Table 2. Solid lines represent patients with ATG levels below the cutoff and broken lines patients with ATG levels above the cutoff. P-values shown are adjusted for covariates (binomial regression multivariate analysis). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions


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