Presentation is loading. Please wait.

Presentation is loading. Please wait.

Reversal Strategies for VKA: Truths and Misconceptions

Similar presentations


Presentation on theme: "Reversal Strategies for VKA: Truths and Misconceptions"— Presentation transcript:

1 Reversal Strategies for VKA: Truths and Misconceptions

2

3 Program Objectives

4 Typical Indications for Anticoagulation Therapy

5 The Coagulation Cascade: Pathways and Factors

6 Coagulation Cascade and Activity Sites of Anticoagulant Therapeutics

7 Warfarin MoA[a,b]

8 Pharmacologic Properties of Selected Oral Anticoagulants

9 Reasons for Urgent Anticoagulation Reversal

10 Reversal Agents for VKA-Associated Anticoagulation

11 VKA Therapy Reversal With Vitamin K

12 FFP for Anticoagulation Reversal

13 Management of Urgent Anticoagulation Reversal

14 Volume Overload and Anticoagulation Reversal With FFP

15 RE-LY Study: Risk of Major Bleeding (% of Patients)

16 Efficacy and Safety of a 4F-PCC in Patients on VKAs Presenting With Major Bleeding: Key Results From a Phase 3b Study

17 Outcomes of Urgent Warfarin Reversal With FFP vs 4F-PCC

18 4F-PCC vs Plasma for Rapid VKA Reversal in Patients Needing Urgent Surgical or Invasive Interventions: Primary Endpoint Results

19 4F-PCC vs Plasma for Rapid VKA Reversal in Patients Needing Urgent Surgical or Invasive Interventions: Adverse Events

20 Increased Risk of Volume Overload With Plasma Compared With 4F-PCC

21 Thromboembolic Events Over Time: Plasma vs 4F-PCC

22 Recombinant FVIIa vs 3F-PCC

23 Warfarin Reversal by 4F-PCC

24 Relative Efficacy of Strategies for Reversal of Oral Anticoagulation

25 Therapeutic Interventions for Reversal of Oral Anticoagulants Based on Urgency[a-e]

26 What Do Guidelines Recommend?

27 Updated European Heart Rhythm Association Practical Guide: Management of NOAC-Associated Bleeding

28 Conclusions

29 Abbreviations

30 Abbreviations (cont)


Download ppt "Reversal Strategies for VKA: Truths and Misconceptions"

Similar presentations


Ads by Google