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Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging

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Presentation on theme: "Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging"— Presentation transcript:

1 Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging
Xiao Tian, Andrei Seluanov, Vera Gorbunova  Cell Metabolism  Volume 25, Issue 5, Pages (May 2017) DOI: /j.cmet Copyright © Terms and Conditions

2 Figure 1 Potential Strategies to Delay Aging Caused by Accumulation of DNA Damage DNA damage leads to aging and functional decline by generating mutations, inducing cellular senescence, and causing metabolic dysregulation due to persistent DNA damage signaling. These deleterious effects of DNA damage can be targeted either individually through elimination of senescent cells or inhibition of DNA-PK, or, more comprehensively, by developing strategies to improve DNA repair. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © Terms and Conditions


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