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Intraoperative physiologic variables and outcome in cardiac surgery: part II. Neurologic outcome  Gijs K van Wermeskerken, MD, Jan-Willem H Lardenoye,

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Presentation on theme: "Intraoperative physiologic variables and outcome in cardiac surgery: part II. Neurologic outcome  Gijs K van Wermeskerken, MD, Jan-Willem H Lardenoye,"— Presentation transcript:

1 Intraoperative physiologic variables and outcome in cardiac surgery: part II. Neurologic outcome 
Gijs K van Wermeskerken, MD, Jan-Willem H Lardenoye, MD, Steven E Hill, MD, Hilary P Grocott, MD, Barbara Phillips-Bute, PhD, Peter K Smith, MD, Joseph G Reves, MD, Mark F Newman, MD  The Annals of Thoracic Surgery  Volume 69, Issue 4, Pages (April 2000) DOI: /S (99)

2 Fig 1 Probability of adverse neurologic event in relation to mean arterial pressure less than 50 mm Hg (MAP < 50) controlling for stroke risk index and cardiopulmonary bypass time. The upper and lower lines represent the 95% confidence intervals. A more negative MAP < 50 (greater time and extent of mean arterial pressure depression less than 50 mm Hg) is associated with a decreased risk of adverse neurologic outcome (p = ; c-index for model = 0.714). The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 Probability of an adverse neurologic event in normal to high (HI) mean arterial pressure (MAP) and low (LO) MAP groups stratified into quartiles by stroke risk index score. The association between lower pressure during cardiopulmonary bypass and less neurologic injury persisted in each of the four risk groups (n = 708 to 731 patients per quartile). The Annals of Thoracic Surgery  , DOI: ( /S (99) )


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