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Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI)–Pretreated Non–Small-Cell.

Published byΑναστασούλα Βουρδουμπάς Modified over 5 years ago

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Presentation on theme: "Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI)–Pretreated Non–Small-Cell."— Presentation transcript:

1 Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI)–Pretreated Non–Small-Cell Lung Cancer Patients with Brain Metastases or Leptomeningeal Disease  Petra Hoffknecht, MD, Amanda Tufman, MD, Thomas Wehler, MD, Theo Pelzer, MD, Rainer Wiewrodt, MD, Martin Schütz, MD, Monika Serke, MD, Jan Stöhlmacher-Williams, MD, Angela Märten, MD, Rudolf Maria Huber, MD, Nicolas J. Dickgreber, MD  Journal of Thoracic Oncology  Volume 10, Issue 1, Pages (January 2015) DOI: /JTO Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Time to treatment failure.
Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Response rates in the patient group with central nervous system metastasis on afatinib. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Patterns of response to afatinib in the patient group with central nervous system metastasis. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Pharmacokinetic and clinical data from case report 1. CSF, cerebrospinal fluid; KPS, Karnofsky performance status. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

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