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Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer  Thomas J. Povsic, MD, PhD,

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Presentation on theme: "Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer  Thomas J. Povsic, MD, PhD,"— Presentation transcript:

1 Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer  Thomas J. Povsic, MD, PhD, Monica G. Lawrence, MD, A. Michael Lincoff, MD, Roxana Mehran, MD, Christopher P. Rusconi, PhD, Steven L. Zelenkofske, DO, Zhen Huang, MS, Jeffrey Sailstad, BS, Paul W. Armstrong, MD, P. Gabriel Steg, MD, Christoph Bode, MD, Richard C. Becker, MD, John H. Alexander, MD, MHS, N. Franklin Adkinson, MD, Arnold I. Levinson, MD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 6, Pages (December 2016) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 A, Relative levels of anti-PEG antibodies by allergy. B, Changes in individual complement levels in patients with severe immediate acute allergic reactions to pegnivacogin. C, Changes in individual complement and tryptase levels by treatment and occurrence and timing of allergy. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © Terms and Conditions

3 Fig 1 A, Relative levels of anti-PEG antibodies by allergy. B, Changes in individual complement levels in patients with severe immediate acute allergic reactions to pegnivacogin. C, Changes in individual complement and tryptase levels by treatment and occurrence and timing of allergy. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © Terms and Conditions

4 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © Terms and Conditions


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