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Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction  Marta Kaminska, MD, Susan Foley, MD, Karim Maghni,

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Presentation on theme: "Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction  Marta Kaminska, MD, Susan Foley, MD, Karim Maghni,"— Presentation transcript:

1 Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction  Marta Kaminska, MD, Susan Foley, MD, Karim Maghni, DSc, PhD, Claudine Storness-Bliss, BSc, Harvey Coxson, PhD, Heberto Ghezzo, PhD, Catherine Lemière, MD, MSc, Ronald Olivenstein, MD, Pierre Ernst, MD, Qutayba Hamid, MD, PhD, James Martin, MD, DSc  Journal of Allergy and Clinical Immunology  Volume 124, Issue 1, Pages e4 (July 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 ASM in endobronchial biopsy specimens. Smooth muscle bundles (shown in brown) are larger in a subject with chronic persistent obstruction (B) than in a subject with intermittent obstruction (A). C, Isotype control (α-smooth muscle actin immunoperoxidase staining). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Correlation between SMA (percentage of total biopsy area) and FEV1 (percent predicted) in subjects with severe asthma. Solid triangles, Subjects with chronic persistent obstruction; open triangles, subjects with intermittent obstruction. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Correlation between Pi10 (a measure of airway wall thickness on HRCT, see the Methods section for details) and RBM thickness (A) and SMA % (B) for 13 subjects who underwent HRCT and a biopsy and between Pi10 and FEV1 percent predicted (from the study visit closest to HRCT; n = 21; C). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Correlation between SMA% on bronchial biopsy and concentrated sputum supernatant cytokines measured with the Bio-Plex assay. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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