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Comprehensive Genomic Profiling of Diagnostic Bone Marrow Specimens Identifies Mutational Profiles Predictive of Relapse in Patients with Acute Myeloid.

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Presentation on theme: "Comprehensive Genomic Profiling of Diagnostic Bone Marrow Specimens Identifies Mutational Profiles Predictive of Relapse in Patients with Acute Myeloid."— Presentation transcript:

1 Comprehensive Genomic Profiling of Diagnostic Bone Marrow Specimens Identifies Mutational Profiles Predictive of Relapse in Patients with Acute Myeloid Leukemia Who Undergo Autologous Hematopoietic Cell Transplantation  Gabriel N. Mannis, MD, Shan Zhong, PhD, Michelle Nahas, PhD, Lily Kahira, MS, Aaron C. Logan, MD, PhD, Charalambos Andreadis, MD, MSCE, Lloyd E. Damon, MD, Rebecca L. Olin, MD, MSCE, Sohail Balasubramanian, MS, Jie He, PhD, Jo-Anne Vergilio, MD, Tariq Mughal, MD, Weiyun Ai, MD, PhD, Karin M.L. Gaensler, MD, Peter Sayre, MD, Jeffrey L. Wolf, MD, Thomas G. Martin, MD  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, Pages S41-S42 (March 2016) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 (A,B) Mutational profiles of relapsers versus non-relapsers in (A) intermediate-risk AML and (B) favorable-risk AML. (C) Relapse-free survival (RFS) of patients with favorable- versus intermediate-risk cytogenetics who underwent autologous hematopoietic cell transplant (autoHCT) for acute myeloid leukemia (AML). Time truncated at 6yrs for clarity. (D) RFS stratified by the presence of the following alterations: FLT3- ITD, NRAS, MLL, or IDH1/2. Time truncated at6yrs for clarity. Biology of Blood and Marrow Transplantation  , S41-S42DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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