4. Pinel 1793
Dementia,
Idiocy,
Mania,
Melancholia

5. On Fantasy Dementia, Mania, Melancolia Vincenzo Chiarugi
Empoli Firenze 1820
On Fantasy
Dementia,
Mania,
Melancolia
דר' פלד – מרכז בה"ן שער מנשה

6. Morel DEMENTIA PRAECOX
Young male becomes demented dysfunctional
Hecker HEBEPHRENIA
Young male, disorganized restless loose associations
Fragmented experiences
Kalbaum CATATONIA
Signs of motor abnormalities freezing, waxy-flexibility

7. Manic depressive psychosis Paranoia (today delusional)
1900
KRAEPLIN
Dementia praecox
Manic depressive psychosis
Paranoia (today delusional)
Based on prognosis medical model
Based on prognosis

8. Mental disorganization
 BLEULER
1920
Mental disorganization
Affect
Associations
Ambivalence
Autism
4 A’s
Schizophrenia
Schizo - Prenus

9. First Rank Symptoms of Schizophrenia
DELUSIONAL PERCEPTION.
AUDITORY HALLUCINATIONS.
DELUSIONS OF THOUGHT INTERFERENCE.
PASSIVITY PHENOMENON OR DELUSIONS OF CONTROL.

12. - + Hallucinations Loosening Delusions restlessness Positive symptoms
 BLEULER
1920
Mental disorganization
Affect Associations Ambivalence Autism
4 A’s
Schizophrenia
Schizo - Prenus
Hallucinations
Loosening
Delusions
restlessness
Poverty thought
Perseverations
Avolition + -
Positive
symptoms
1900
KRAEPLIN
Dementia praecox
Based on prognosis
Negative
symptoms
Function
Age 18

14. What Causes Schizophrenia ?

16. Henri Laborit

21. + + - -

22. Ego Letters, the project Theodore Meynert (1833-1892) Carl Wernicke
( )
Letters, the project

25. Gregory Bateson (9 May 1904 – 4 July 1980)

27. Lyman C Wynne

28. Ego Letters, the project Theodore Meynert (1833-1892) Carl Wernicke
( )
Letters, the project

29. Disconnection Syndrome Psychosis
The associations of an adult ego
could be temporarily or permanently weakened,
with a similar result of random or confused
thought processes. … resulting
in psychotic states.
Theodore Meynert
( )
Disconnection Syndrome
Psychosis

30. Disconnection Syndrome
Theodore Meynert
( )
Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis.
J Neurosci Nov 24;30(47):
van den Heuvel MP, Mandl RC, Stam CJ, Kahn RS, Hulshoff Pol HE our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs, resulting in a limited structural capacity to integrate information across brain regions
Yu Q, Sui J, Rachakonda S, He H, Pearlson G, Calhoun VD. Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task. Front Syst Neurosci Feb 8;5:7.
Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A. Dysconnectivity in schizophrenia: Where are we now? Neurosci Biobehav Rev Apr;35(5): Review
Guye M, Bettus G, Bartolomei F, Cozzone PJ. Theoretical analysis of structural and functional connectivity MRI in normal and pathological brain networks. MAGMA Dec;23(5-6): Epub 2010 Mar 27.Graph
Bassett DS, Bullmore E, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A. Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci Sep 10;28(37):
Bodnar M, Harvey PO, Malla AK, Joober R, Lepage M. The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study. Clin Schizophr Relat Psychoses Jan;4(4):
Jones MW. Errant ensembles: dysfunctional neuronal network dynamics in schizophrenia. Biochem Soc Trans Apr;38(2): Review
Psychosis
Disconnection Syndrome

32. Giulio Tononi
Order
Randomness
Complexity
Neural
Complexity
Disconnection
dynamics
Over-connection
dynamics 32

40. Hopfield type architecture

41. Formulate brain dynamics as a physical state-space dynamic system

44. Psychological
Event
Computational
Psychiatry
Biological
Biological
Event

45. Computational
Psychiatry
Biological
Explanatory
Power

48. Cs connectivity segregation
All of the various brain disturbances are mapped onto a 9 axis profile “the Clinical Brain Profile (CBP) Cs Ci
Htd
Hbu D O CF
CF(b)
DMN
Clinical Brain Profiling (CBP)
Cs connectivity segregation
Optimal brain
Disturbance
to plasticity and
Optimization
Ci connectivity
integration
Htd Hierarchal
top down shift
Hbu Hierarchal
Bottom-up
insufficiency
D De-optimization
O Hyper-
optimization
CF Constrain
Frustration
CF(b) Constrain
Bound
Default
Mode
Network
to connectivity

51. Clinician User Integrated Brain Profiler
User report
User
report
Sensors
Extract
Phenomenology
EEG
Brain
Imaging
Synchronize
Clinician report

59. tACS Transcranial Alternating Current Stimulation