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Unraveling the genetic predisposition of ribavirin-induced anaemia

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1 Unraveling the genetic predisposition of ribavirin-induced anaemia
Tarik Asselah, Eric Pasmant, Saïd Lyoumi  Journal of Hepatology  Volume 53, Issue 5, Pages (November 2010) DOI: /j.jhep Copyright © Terms and Conditions

2 Fig. 1 ITPA deficiency protects against clinically significant RBV-induced decline in Hb concentration. Adapted from Felay et al. [10]. Percentages of clinically significant anaemia at week 4 (defined as either a decline in Hb of >3g/dl and/or Hb levels <10g/dl) are shown according to rs and rs combined genotypes. Rs and rs minor variants confer reduced ITPA and induce protection against clinically significant haemolytic anaemia in hepatitis C-infected patients receiving RBV. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © Terms and Conditions


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