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The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma  Akane Tanaka, BSc, Venkata.

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Presentation on theme: "The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma  Akane Tanaka, BSc, Venkata."— Presentation transcript:

1 The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma  Akane Tanaka, BSc, Venkata Sita Rama Raju Allam, MS Pharm, Jennifer Simpson, BBiomedSc, Natalia Tiberti, PhD, Jenna Shiels, BSc, Joyce To, BSc, Maria Lund, PhD, Valery Combes, PhD, Sinead Weldon, PhD, Cliff Taggart, PhD, John P. Dalton, PhD, Simon Phipps, PhD, Maria B. Sukkar, PhD, Sheila Donnelly, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 6, Pages (June 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 FhHDM-1 modulates macrophage gene expression. A, Clustered profiles for all genes expressed in macrophages that were untreated, treated with LPS (10 ng/mL) or treated with LPS (10 ng/mL) and FhHDM-1 (15 μmol/L). Changes in fold expression are depicted for 2 experimental replicates. The color-code key indicates fold increases (red) or decreases (blue) in gene expression. B, Putative canonical pathways significantly altered by FhHDM-1 in macrophages treated with LPS for 6 hours, as determined by IPA analysis. The color-code key indicates the extent of activation (orange) or inhibition (blue) of a pathway. LXR/RXR, Liver X receptor/retinoid X receptor; PI3K, phosphoinositide 3-kinase; R1G1, retinoic acid inducible gene 1; TREM, triggering receptor expressed on myeloid cell. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 FhHDM-1 protects against experimental asthma. A, Study design. B, Total and differential cell counts in BALF. C, Total lung resistance and tissue resistance measured by forced oscillation technique using FlexiVent apparatus (SCIREQ, Montreal, Quebec, Canada). D, Lung inflammation score and airway mucus score as assessed by hematoxylin and eosin (H&E) and periodic-acid Schiff (PAS) staining, respectively. Representative images of H&E (upper panel, ×10 original magnification) and PAS (lower panel, ×40 original magnification) are shown. Bars = 60 μm. Data represent means ± SEMs. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 versus mice treated with PBS. #P < .05 and ##P < .01 versus mice treated with house dust mite (HDM). n = 6 to 8 mice per group. MCh, Methacholine. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1A Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E1B Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E3 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E4 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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