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Management of Carcinoid Tumors

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1 Management of Carcinoid Tumors
Frank C. Detterbeck, MD  The Annals of Thoracic Surgery  Volume 89, Issue 3, Pages (March 2010) DOI: /j.athoracsur Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Age distribution of patients with bronchial carcinoid tumors (line graph) [14–19] and percentage of carcinoid tumors that are atypical by decades of age (bar graph) [14–16] is shown. Data are based on reports using the 1972 classification system [11]. (Reproduced with permission from Kiser AC, Detterbeck FC. Carcinoid and mucoepidermoid tumors. In: Detterbeck FC, Rivera MP, Socinski MA, Rosenman JG (eds), Diagnosis and Treatment of Lung Cancer: An Evidence-Based Guide for the Practicing Clinician. Philadelphia, PA: W. B. Saunders; 2001:379–393 [8].) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Distribution of (left panel) central and (right panel) peripheral carcinoids (both typical and atypical) is shown. Values represent an average taken from studies of 50 or more patients from 1975 to 2007 [14, 17, 20–26]. (BI = bronchus intermedius; LLL = left lower lobe; LMSB = left mainstem bronchus; LUL = left upper lobe; RLL = right lower lobe; RML = right middle lobe; RMSB = right mainstem bronchus; RUL = right upper lobe.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Calculated proportion of typical (TC) and atypical carcinoid (AC) tumors among bronchopulmonary carcinoids is shown by location and pathologic nodal status. The calculations are based on the following data and assumptions [2]: (1) TC accounts for 83% of all central carcinoids, 69% of all peripheral carcinoids; (2) the proportion of N0, N1, N2 is 90%, 8% and 2% for TC and 60, 22 and 18% for AC. The proportions are assumed to be the same for a TC (or AC) whether the tumor is central or peripheral. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Overall survival is shown for patients with a pN0 (n = 517) or pN1,2 (n = 52) typical carcinoid. (Reproduced with permission from Garcia-Yuste M, Matilla JM, Cueto A, et al. Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung. Eur J Cardiothorac Surg 2007;31:192–197 [9]). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Overall survival of patients with a pN0 (n = 59) or pN1, 2 (n = 33) atypical carcinoid. (Reproduced with permission from Garcia-Yuste M, Matilla JM, Cueto A, et al. Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung. Eur J Cardiothorac Surg 2007;31:192–197 [9]). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions


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