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Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy  Harold Nelson, MD, Shannon Cartier, MSc,

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Presentation on theme: "Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy  Harold Nelson, MD, Shannon Cartier, MSc,"— Presentation transcript:

1 Network Meta-analysis Shows Commercialized Subcutaneous and Sublingual Grass Products Have Comparable Efficacy  Harold Nelson, MD, Shannon Cartier, MSc, Felicia Allen-Ramey, PhD, Simon Lawton, MD, Moises A. Calderon, MD  The Journal of Allergy and Clinical Immunology: In Practice  Volume 3, Issue 2, Pages e3 (March 2015) DOI: /j.jaip Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Figure 1 NMA practical approach. A, Network diagram: Dotted line indicates indirect comparison; solid line, direct comparison. B, NMA: Brief identification of steps involved in the estimation of comparisons in the network. Step 1: Data identified from the studies are pooled to estimate the treatment effects compared with placebo. Step 2: The relative treatment effects compared with placebo are then used to calculate the indirect comparisons. D, Drops; T, tablets. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Figure 2 Study selection flow diagram.
The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Figure 3 Direct comparison for symptom scores of immunotherapy treatment options versus placebo. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Figure 4 Direct comparison for medication scores of immunotherapy treatment options versus placebo. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Figure E1 Forest plots for symptom scores.
The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Figure E2 Funnel plots for each immunotherapy modality vs placebo. The funnel plots for SCIT symptom scores and SLIT-D symptom and medication scores appear to be sporadic. The funnel plots for SCIT medication scores, and SLIT-T symptom and medication scores, however, visually appear to have some asymmetry, lacking studies in the middle to lower section of the right-hand side of the funnel. D, Drops; T, tablets. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, e3DOI: ( /j.jaip ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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