1. © The Author(s) 2018. Published by Science and Education Publishing.
Table 1. Demographic and Body Composition Characteristics of Subjects with Thalassemia
Total
Male
Female
p-valuea
No. of subjects 41 20 21
Age (years)b
28.3±10.8
26.7±9.7
29.9±11.8 NS
Adolescents (%)
24.4
10, (50%)
Height (cm)
158.7 ± 11.0
162.4±12.8
155.2±7.7
0.03
Weight (kg)
56.4 ± 16.5
56.2±15.0
56.7±18.1
BMIc (kg/m2)
22.1 ± 5.2
20.1±3.9
23.3±6.1
Race (% of total)
Caucasian
12.2
0.0
23.8
Asian
56.1
65.0
47.6
South Asian
17.1
20.0
14.3
Middle Eastern
14.6
15.0
Thalassemia Classification (% of total)
ß-Thal
83.0
80.0
85.7
E-β Thal
12.0 15
9.5
α Thal
5.0
4.8
Liver iron concentratione (mg Fe/g dry tissue)
1.6±1.26
1.3±1.0
1.4±1.3
Lean Mass Z-Scoref
0.13±0.15
0.12±0.08
0.14±0.20
Fat Mass Z-Scoref
0.24±0.75
0.10±0.80
0.36±0.71
a,b For continuous variables, data is presented as mean ±SD, and p-values are generated from analysis of variance for difference between males and females. For categorical variables, data is presented as a % of total subject’s population p-values are from chi-squared with Fisher’s exact follow-up test. P-values were considered statistically significant at a level of p<0.05.
c BMI: body mass index, calculated as kg/m2.
d Includes subjects with HbH/CS=hemoglobin H/Constant Spring.
e Liver iron concentration was determined by superconducting quantum interference device (SQUID). The LIC measured in mcg/g wet-liver-weight was converted to dry-liver-weight using the formula mcg/g wet-liver-weight x 6/1000 = mg/g dry-liver-weight
f Lean & Fat Mass obtained from DXA; Z-scores calculated from National Health and Nutrition Examination Survey Reference Data 2008: Kelly TL, Wilson KE, Heymsfield SB. Dual energy X-Ray absorptiometry body composition reference values from NHANES. PLoS One. 2009; 4(9): e7038.
Elijah K Goldberg et al. Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated
with Iron Overload.
Journal of Food and Nutrition Research, 2018, Vol. 6, No. 10, doi: /jfnr
© The Author(s) Published by Science and Education Publishing.