1. Eosinophil extracellular DNA traps in skin diseases
Dagmar Simon, MD, Susanne Hoesli, MD, Nina Roth, Simon Staedler, Shida Yousefi, PhD, Hans-Uwe Simon, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 127, Issue 1, Pages (January 2011)
DOI: /j.jaci
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Eosinophil extracellular traps (arrows). Accumulation of eosinophils releasing DNA (red) and ECP (green) in BP. DNA plus ECP, overlay (A), DNA (B), ECP (C).
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Release of ECP by eosinophils. A, A single eosinophil generating an EET consisting of DNA (red) and ECP (green) in larva migrans. B, Broad fibrous structures covered with ECP (green) forming a flame figure in WS. C, EETs (arrows) and eosinophil granule depositions with ECP (green; arrowheads) in WS. DNA was stained with PI (red). Magnification ×1000.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
IL-5 and eotaxin–expressing cells in skin tissues containing EETs. A, IL-5–expressing (green) and CD4-positive (red) cells in APT. Double-positive cells (yellow) are indicated by arrows, single IL-5–expressing cells (green) by arrowheads. Single CD4-positive cells (red) are also visible. B, Eotaxin-2–positive cells in BP. Eosinophils (arrows) and noneosinophilic cells (arrowhead) express eotaxin-2.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
Cleaved caspase-3 expression and EETs in BP. A, Caspase-3–positive cells throughout the epidermis, beneath eosinophils (arrows) in the dermis. Nuclei were counterstained with PI. B-D, Eosinophil at the dermal-epidermal junction (dashed line) generating an EET (arrow). DNA plus ECP, overlay (B), DNA (C), ECP (D). Magnification ×400 (A), ×1000 (B-D).
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions