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The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid
X. Tong, N. Ratnaraj, P.N. Patsalos Seizure - European Journal of Epilepsy Volume 16, Issue 1, Pages (January 2007) DOI: /j.seizure Copyright © 2006 British Epilepsy Association Terms and Conditions
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Figure 1 Vigabatrin concentration vs. time profiles in serum after 250mg/kg (♦), 500mg/kg (■) and 1000mg/kg (▴) vigabatrin administration. Data are mean±S.E.M. of 6–7 animals. Seizure - European Journal of Epilepsy , 43-49DOI: ( /j.seizure ) Copyright © 2006 British Epilepsy Association Terms and Conditions
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Figure 2 Vigabatrin free/total concentration ratio at different vigabatrin concentrations (13–1378μmol/l) over time. Seizure - European Journal of Epilepsy , 43-49DOI: ( /j.seizure ) Copyright © 2006 British Epilepsy Association Terms and Conditions
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Figure 3 Vigabatrin concentration vs. time profiles in CSF after 250mg/kg (▴), 500mg/kg (♦) and 1000mg/kg (■) vigabatrin administration. Data are mean±S.E.M. of 6–7 animals. Seizure - European Journal of Epilepsy , 43-49DOI: ( /j.seizure ) Copyright © 2006 British Epilepsy Association Terms and Conditions
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Figure 4 Relationship between vigabatrin concentrations in serum and CSF. Data are those from 500mg/kg vigabatrin administration. The equation for linear regression is y= ; r2= Seizure - European Journal of Epilepsy , 43-49DOI: ( /j.seizure ) Copyright © 2006 British Epilepsy Association Terms and Conditions
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Figure 5 CSF/serum vigabatrin concentration ratios vs. time after 250mg/kg (■), 500 (♦) and 1000 (▴) mg/kg vigabatrin administration. Data are mean±S.E.M. of 6–7 animals. Seizure - European Journal of Epilepsy , 43-49DOI: ( /j.seizure ) Copyright © 2006 British Epilepsy Association Terms and Conditions
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