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Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

Published byHarriet Baker Modified over 5 years ago

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Presentation on theme: "Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)"— Presentation transcript:

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5 Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

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7 ATP used to Initiate β-oxidation

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10 Page 746

11 NADPH

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15 Cascade for Biosynthesis of Eicosanoids
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16 Biosynthesis of Eicosanoids
Mammals (unsaturation anabolism) C9 Plants (unsaturation anabolism) Arachadonic Acid (ω-6) Cleaved from phospholipids via a phospholipase Cyclooxygenases Prostaglandins (thromboxanes) Leukotrienes 3

17 COX catalyzed reaction
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18 COX Inhibitors 5

19 COX Inhibitors 5

20 Aspirin – Mode of Action
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